Chinese medicine believes “heart governing blood and vessels” and “heart governing mental activitieselieves edic g that “the heart of blood and vessels” and “the heart of mental activities” are two hearts in one with physiological dependence and pathological mutual damage，and advocating “to treat the two hearts(psyco-cardiological disease)at the same time”.The main pathogenesis of psyco-cardiological disease is “qi deficiency and blood stasis”.Yangxinshi Tablets can improve myocardial blood supply，relieve clinical symptoms，stabilize emotions，and improve anxiety and depression symptoms of patients by benefiting qi and activating blood，dissolving stasis and relieving pain，as well as eliminating irritability，relieving anxiety and tranquilizing，so as to achieve the goal of psyco-cardiological harmony，which is suitable for psyco-cardiological treatment of coronary heart disease.Based on the research progress of modern times，this paper analyzes the prescription characteristics of Yangxinshi，and provides a new way of thinking for the treatment of psyco-cardiological disease by combining traditional Chinese and western medicine.