| 引用本文:孙琮，王士汉，张阳阳，杨兴嫕.祛瘀汤联合GP化疗治疗阴虚内热型晚期肺癌的疗效观察[J].世界中医药,2019,(09):. |
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| 祛瘀汤联合GP化疗治疗阴虚内热型晚期肺癌的疗效观察 |
| Observation on Therapeutic Effect of Quyu Decoction Combined with GP Chemotherapy in Treatment of Advanced Lung Cancer with Yin Deficiency and Endogenous Heat |
| 投稿时间：2019-03-19 |
| DOI：10.3969/j.issn.1673-7202.2019.09.035 |
| 中文关键词: 祛瘀汤 GP化疗 阴虚内热 晚期肺癌 肿瘤标志物 |
| English Keywords:Quyu Decoction GP chemotherapy Yin deficiency and endogenous heat Advanced lung cancer Tumor marker |
| 基金项目:安徽中医药大学科研项目(2014mzfyjs004) |
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| 中文摘要: |
| 目的:探讨祛瘀汤联合GP化疗治疗阴虚内热型晚期肺癌的疗效及对患者血清肿瘤标志物的影响。方法:选取2016年3月至2018年3月六安市中医院收治的晚期肺癌患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例,对照组应用GP化疗方案进行治疗,观察组应用祛瘀汤联合GP化疗方案进行治疗。分别对2组患者的临床疗效、肿瘤标志物、血小板指标、凝血功能、纤溶系统以及中医症候积分等相关指标进行客观比较。结果:观察组疗效优于对照组(P<0.05);观察组肿瘤标志物水平明显低于对照组(P<0.05);观察组血小板指标水平变化与对照组差异无统计学意义(P>0.05);观察组凝血功能指标水平变化与对照组差异无统计学意义(P>0.05);观察组纤溶系统指标改善情况明显优于对照组,差异有统计学意义(P<0.05);另外,2组间治疗前后的中医症候积分比较,差异有统计学意义(P<0.05),其中以观察组治疗后的改善程度最为显著。结论:在针对阴虚内热型晚期肺癌的治疗过程当中,采用祛瘀汤联合GP化疗方案治疗的效果理想,且可以有效缓解患者的中医症候,临床上应当进一步推广应用。 |
| English Summary: |
| To explore the therapeutic effects of Quyu Decoction combined with GP chemotherapy in the treatment of advanced lung cancer with yin deficiency and endogenous heat and its effect on serum tumor markers in patients.Methods:A total of 78 patients with advanced lung cancer admitted to Traditional Chinese Hospital of Luan from March 2016 to March 2018 were selected,and the enrolled patients were divided into a control group and an observation group with 39 patients in each group according to the random number table method.The control group was treated with GP chemotherapy regimen,and the observation group was treated with Quyu Decoction combined with GP chemotherapy regimen.The clinical efficacy,tumor markers,platelet index,coagulation function,fibrinolytic system and TCM syndrome score of the 2 groups were compared objectively.Results:The therapeutic effect of the observation group was better than that of the control group(P<0.05).The level of tumor markers in the observation group was significantly lower than that in the control group(P<0.05).There was no significant difference in platelet index level between the observation group and the control group(P>0.05).There was no significant statistic difference in coagulation function between the observation group and the control group.The improvement of fibrinolytic system indicators in the observation group was significantly better than that in the control group,with statistical difference(P<0.05); In addition,there were significant statistical differences in TCM syndrome scores between the 2 groups before and after treatment(P<0.05)in which the observation group showed the most significant improvement after treatment..Conclusion:Quyu Decoction combined with GP chemotherapy is effective in the treatment of advanced lung cancer with yin deficiency and endogenous heat. |
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