| 引用本文:俞平1，马常娥2，王婕2.半夏白术天麻汤联合血府逐瘀汤对高血压患者内皮功能的影响[J].世界中医药,2019,(09):. |
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| 半夏白术天麻汤联合血府逐瘀汤对高血压患者内皮功能的影响 |
| Effects of Banxia Baishu Tianma Decoction Combined with Xuefu Zhuyu Decoction on Endothelial Function of Hypertensive Patients |
| 投稿时间：2019-05-22 |
| DOI：10.3969/j.issn.1673-7202.2019.09.041 |
| 中文关键词: 高血压 一氧化氮 内皮素 半夏白术天麻汤 血府逐瘀汤 疗效 内皮素-1 |
| English Keywords:Hypertension Nitric oxide Endothelin Banxia Baishu Tianma Decoction Xuefu Zhuyu Decoction Therapeutic effect ET-1 |
| 基金项目:甘肃省高等学校科研项目（2018B-051） |
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| 中文摘要: |
| 目的：探讨半夏白术天麻汤联合血府逐瘀汤对高血压患者内皮功能的影响。方法：选取2015年1月至2017年6月河西学院附属张掖人民医院收治的高血压患者80例作为研究对象，按照随机数字表法分为对照组和观察组，每组40例。对照组给予常规西药治疗，观察组在对照组的基础上给予半夏白术天麻汤联合血府逐瘀汤进行治疗，观察和比较治疗后2组患者的血管内皮因子一氧化氮（NO）和内皮素-1(ET-1)水平、疗效、血压以及中医证候积分情况。结果：治疗后，观察组患者治疗有效率为92.50%，对照组患者的治疗有效率为72.50%，差异有统计学意义（P<0.05）；治疗后，2组患者舒张压和收缩压均下降，且观察组舒张压和收缩压下降较对照组显著，差异有统计学意义（P<0.05）；2组患者的血管内皮因子NO水平升高，而ET-1水平下降，且观察组血管内皮因子水平的变化较对照组明显，差异有统计学意义（P<0.05）。治疗后，2组患者中医证候积分均下降，且观察组中医证候积分下降较对照组显著，差异有统计学意义（P<0.05）。结论：半夏白术天麻汤联合血府逐瘀汤能显著升高高血压患者的血清NO水平、降低ET-1水平，有效降低患者血压，具有较好的临床效果。 |
| English Summary: |
| To explore the effects of Banxia Baishu Tianma Decoction combined with Xuefu Zhuyu Decoction on endothelial function in hypertensive patients.Methods:A total of 80 hypertensive patients admitted to Zhangye People's Hospital Affiliated to Hexi University from January 2015 to June 2017 were divided into a control group and an observation group with 40 patients in each group according to random number table method.The control group was given the routine western medicine treatment,and the observation group was treated with Banxia Baishu Tianma Decoction combined with Xuefu Zhuyu Decoction on the basis of the control group.The levels of vascular endothelial factor(NO and ET-1 level),the therapeutic effect,blood pressure and TCM syndrome score were observed and compared between the 2 groups after treatment.Results:After treatment,the total effective rate in the observation group was 92.50% and the total effective rate in control group was 72.50%.The difference between the 2 groups was statistically significant(P<0.05).The diastolic blood pressure and systolic blood pressure all decreased in both groups and the decline in the observation group was more obvious than those in the control group(P<0.05).The levels of NO of the 2 groups patients increased,while the levels of ET-1 all decreased,and the changes in the observation group were more significant than that in the control group(P<0.05).The TCM syndrome score all decreased in both groups and the decline in the observation group was more obvious than those in the control group(P<0.05).Conclusion:Banxia Baishu Tianma Decoction combined with Xuefu Zhuyu Decoction can significantly increase the level of NO and reduce the level of ET-1,effectively decrease the blood pressure in hypertensive patients,which has a good clinical effect and is worthy of promotion and application. |
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