世界中医药
今天是
首页期刊简介会议与培训编委会理事会投稿指南期刊订阅广告合作联系我们读者留言
文章摘要
引用本文:王国军，师强.半夏白术天麻对中风后眩晕的疗效及部分机制研究[J].世界中医药,2019,(09):.  
半夏白术天麻对中风后眩晕的疗效及部分机制研究
Study on Therapeutic Effects and Part Mechanism of Banxia Baizhu Tianma Decoction on Vertigo after Stroke
投稿时间：2018-05-16  
DOI：10.3969/j.issn.1673-7202.2019.09.046
中文关键词:  中风病  眩晕  风痰阻络型  DHI  运动功能  平衡能力  日常生活能力  半夏白术天麻汤  NPY  ET-1
English Keywords:Stroke  Vertigo  Syndrome of wind phlegm obstructing the collaterals  DHI  Movement function  Balance Function  Daily living ability  Banxia BaizhuTianma Decoction  NPY  ET-1
基金项目:2014年陕西省科技计划项目（2014K02-11-01）
作者单位
王国军，师强 延安大学附属医院，延安，716000 
摘要点击次数: 557
全文下载次数: 469
中文摘要:
      目的：评价半夏白术汤对中风后眩晕的临床疗效，并观察其对血浆中神经肽Y、血浆内皮素-1浓度的影响。方法：选取2015年1月至2016年1月延安大学附属医院收治的风痰阻络型中风后眩晕患者60例作为研究对象，按照随机数字表法分为对照组和观察组，每组30例。2组患者均接受中风病神经内科常规治疗，对照组在常规治疗基础上加用倍他司汀、氟桂利嗪胶囊，观察组在对照组治疗基础上加用半夏白术天麻汤，200 mL煎服，早晚温服分服，2组均连续治疗15 d，比较2组患者临床有效率、Fugl-Meyer运动功能量表评分、WOLF运动能力测试量表评分、Berg平衡量表评分以及功能独立性量表评分的变化，同时检测治疗前后外周血NPY、ET-1浓度的变化情况。结果：观察组临床总有效率93.34%，对照组为73.33%，2组比较差异有统计学意义（P<0.05）；治疗前2组患者眩晕残障量表评分、Fugl-Meyer评分、WOLF评分、Berg平衡量表评分、功能独立性量表评分与外周血NPY、ET-1水平差异无统计学意义（P>0.05），治疗后2组眩晕残障量表评分均有下降，其中观察组下降得趋势更明显，差异有统计学意义（P<0.05）；Fugl-Meyer评分、WOLF评分和Berg平衡量表评分均高于治疗前，差异有统计学意义（P<0.05），且观察评分均优于对照组，差异有统计学意义（P<0.05）；日常生活能力均较治疗前得到改善，差异有统计学意义（P<0.05），其中观察组中改善得较对照组明显，差异有统计学意义（P<0.05）；眩晕残障量表评分与外周血NPY、ET-1水平均下降，差异有统计学意义（P<0.05），且NPY、ET-1浓度具有正相关关系。结论：半夏白术天麻汤对风痰阻络型眩晕有理想疗效，其作用机制可能与下调NPY、ET-1表达有关。
English Summary:
      To evaluate the clinical effect of Banxia Baizhu Tianma Decoction on vertigo after stroke,and observe its effect on plasma neuropeptide Y(NPY)and plasma endothelin 1(ET-1)concentration.Methods:From January 2015 to January 2016,60 cases of vertigo after wind phlegm obstructing the collaterals treated by Yanan University Affiliated Hospital were divided into a control group and an observation group,with 30 cases in each group.Two groups of patients received conventional medical treatment of stroke,in addition to that,the control group was treated by betahistine and Flunarizine Capsules.On the basis of the control group,the observation group was treated with Banxia Baizhu Tianma Decoction,200 mL,taken separately in morning and evening along with warm water.The two groups were treated for 15 days and the clinical efficiency,Fugl-Meyer motor function scale and WOLF motor ability test scale(WOLF)score,Berg balance scale(BBS)and functional independence score(FIM)changes were compared between the 2 groups.At the same time,changes of peripheral blood NPY and ET-1 concentration were detected before and after treatment.Results:The total efficiency of the observation group was 87%,control group was 66% and there was significant difference between the 2 groups(χ2=2.89,P<0.05); Before the treatment the dizziness handicap scale(DHI),Fugl-Meyer score,WOLF score,BBS score,FIM,SF-36 score,DHI score and peripheral blood NPY and ET-1 showed no significant difference(P>0.05).After treatment,DHI score in the 2 groups decreased,and the observation group decrease trend was more significantly(P<0.05); Two groups of Fugl-Meyer score,WOLF score and BBS score were higher than that of before the treatment(P<0.05),and the observation scores were better than the control group(P<0.05); The ability of daily life of the 2 groups of patients after treatment was better than that of before the treatment(P<0.05)and the observation group improved more significantly compared with the control group(P<0.05); DHI score and the concentration of NPY and ET-1 in the peripheral blood of the 2 groups decreased(P<0.05),and NPY and ET-1 levels had a positive correlation.Conclusion:Banxia Baizhu Tianma Decoction has an ideal effect on wind phlegm obstructing vertigo,and its mechanism may be related to the decreased expression of NPY and ET-1.
查看全文  查看/发表评论  下载PDF阅读器
京ICP备14052068号-2
版权所有 ：《世界中医药》杂志社
技术支持：北京勤云科技发展有限公司