世界中医药
文章摘要
引用本文:王海琳1,李宣霖1,刘冉1,余海滨2,余学庆1.补肺活血胶囊联合西医常规治疗慢性阻塞性肺病Meta分析[J].世界中医药,2019,(11):.  
补肺活血胶囊联合西医常规治疗慢性阻塞性肺病Meta分析
Meta-analysis of Bufei Huoxue Capsules Cooperated with Western Medicine for Chronic Obstructive Pulmonary Disease
投稿时间:2018-07-09  
DOI:10.3969/j.issn.1673-7202.2019.11.021
中文关键词:  补肺活血胶囊  慢性阻塞性肺疾病  随机对照试验  Meta分析  西药  研究质量  联合  有效性
English Keywords:Bufei Huoxue capsule  Chronic obstructive pulmonary disease  Randomized controlled trial  Meta-analysis  Western medicine  Research quality  Combination use  Effectiveness
基金项目:国家自然科学基金面上项目(81473799)
作者单位
王海琳1,李宣霖1,刘冉1,余海滨2,余学庆1 1 河南中医药大学第一附属医院郑州450000 2 河南中医药大学/呼吸疾病诊疗与新药研发河南省协同创新中心/河南省中医药防治呼吸病重点实验室郑州450046 
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中文摘要:
      目的:系统评价补肺活血胶囊联合西医常规治疗慢性阻塞性肺疾病(COPD)有效性及安全性。方法:选取计算机检索Embase,PubMed,Cochrane Library,中国知网(CNKI)、万方数字化期刊全文数据(WANFANG DATA)、维普中文期刊数据库(VIP)、中国生物医学文献数据库(SinoMed),收集补肺活血胶囊治疗COPD随机对照研究,检索时限均为从建库至2017年12月。采用RevMan.5.3软件进行数据分析,并按照国际证据评价与推荐GRADE标准进行证据质量评价。结果:共纳入7个随机对照试验,共计662例COPD患者。补肺活血胶囊联合西医常规治疗COPD与单用西医常规比较,联合组在减少急性加重次数、提高6 min步行距离(6MWT)、减少咳嗽、咳痰、喘息症状积分、提高肺功能、降低圣乔治问卷积分(SGRQ)方面差异有统计学意义(P<0.05);但2组患者在提高治疗有效率方面差异无统计学意义(P>0.05)。在进行敏感性分析后,结果发生逆转,则说明效应值敏感性高,稳定性差。不良反应方面,未见补肺活血解毒胶囊应用的不良反应报道。结论:补肺活血胶囊联合西医常规治疗COPD的疗效优于单用西医常规治疗。但由于纳入研究的质量偏低,且缺乏大样本证据支持,故临床上使用该证据进行决策仍需慎重。
English Summary:
      To systematically evaluate the efficacy and safety of Bufei Huoxue Capsules combined with western medicine in the treatment of chronic obstructive pulmonary disease(COPD).Methods:Computers were searched for Embase,PubMed,Cochrane Library,SinoMed,CNKI,VIP,and WANFANG DATA databases.Randomized controlled trials of Bufei Huoxue Capsules for the treatment of COPD were collected.The time limit for the search was from building database to December 2017.RevMan.5.3 software was used for data analysis,and the quality of evidence was evaluated according to the international evidence evaluation and recommended GRADE criteria.Results:A total of 7 randomized controlled trials were included with 662 patients with COPD.Meta-analysis showed that the combination of Bufei Huoxue capsules and western medicine in the treatment of COPD was associated with a reduction in the number of acute exacerbations,an increase in 6-minute walking distance(6MWT),a reduction in cough,sputum,wheezing symptom scores,and an increase in lungs compared with western medicine alone.There was a statistically significant difference in function and SGRQ scores(P<0.05); however,there was no significant difference between the 2 groups in improving total effective rate(P>0.05).After sensitivity analysis,the results were analyzed.A reversal occurred,indicating that the effect had high sensitivity and poor stability.Regarding adverse reactions,no adverse reactions reported by Bufei Huoxue Capsule were reported.Conclusion:Based on the existing clinical evidence,the therapeutic effects of Bufei Huoxue Capsules combined with conventional western medicine treatment of COPD is better than that of western medicine alone.However,due to the low quality of the included studies and the lack of support for large sample evidence,clinical use of this evidence for decision-making still requires caution.
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