世界中医药
文章摘要
引用本文:朱新庆,张奇志.麝香保心丸对急性心肌梗死患者心功能的影响及相关机制探讨[J].世界中医药,2019,(11):.  
麝香保心丸对急性心肌梗死患者心功能的影响及相关机制探讨
Effects of Shexiang Baoxin Pills on Cardiac Function in Patients with Acute Myocardial Infarction and its Related Mechanism
投稿时间:2018-10-30  
DOI:10.3969/j.issn.1673-7202.2019.11.031
中文关键词:  急性心肌梗死  麝香保心丸  心功能  血管新生  炎性反应  血管内皮生长因子  碱性成纤维细胞生长因子  降钙素原
English Keywords:Acute myocardial infarction  Shexiang Baoxin Pills  Heart function  Angiogenesis  Inflammatory reaction  Vascular endothelial growth factor  Basic fibroblast growth factor  Procalcitonin
基金项目:山东省医药卫生科技发展计划项目(2015WS0390)
作者单位
朱新庆,张奇志 山东省立第三医院济南250031 
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中文摘要:
      目的:分析麝香保心丸对急性心肌梗死(AMI)患者心功能的影响。方法:选取2014年9月至2018年2月山东省立第三医院收治的AMI患者118例作为研究对象,按照治疗方案不同分为对照组(n=60)和观察组(n=58)。对照组接受常规溶栓治疗,观察组在溶栓治疗基础上加入麝香保心丸治疗,以14 d为1个疗程。对比2组患者治疗前后左室射血分数(LVEF)、每搏输出量(SV)等心功能参数水平的变化,以及血清血管新生指标:血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF),及炎性反应因子:肿瘤坏死因子α(TNF-α)、降钙素原(PCT)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)含量的差异。结果:治疗前,2组患者心功能参数水平及血清血管新生指标、炎性反应因子含量比较,差异无统计学意义(P>0.05)。治疗14 d后,观察组患者LVEF、SV的水平高于对照组患者;血清中VEGF、bFGF的含量高于对照组患者;血清中TNF-α、PCT、IL-1β、IL-6的含量低于对照组患者,差异有统计学意义(P<0.05)。结论:AMI患者在溶栓治疗同时加入麝香保心丸联合治疗,可进一步优化机体心功能,具体机制可能与麝香保心丸促血管新生、抗炎等作用相关。
English Summary:
      To analyze the effects of Shexiang Baoxin Pills on cardiac function in patients with acute myocardial infarction(AMI).Methods:A total of 118 cases of AMI patients who were treated in Shandong Provincial Third Hospital during September 2014 to February 2018 were chosen as research subjects.Treatment methods were retrospectively analyzed,and all patients were divided into a control group(n=60)underwent conventional thrombolytic therapy,and a study group(n=58)underwent Shexiang Baoxin Pills combined with thrombolytic therapy.14 d was used as a course.The changes of left ventricular ejection fraction(LVEF)and stroke volume(SV)were compared before and after treatment between the 2 groups,as well as serum angiogenesis indexes [vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)] and inflammatory factors [tumor necrosis factor α(TNF-α)and calcitonin(PCT),interleukin-1β(IL-1β),interleukin-6(IL-6)].Results:Before treatment,there were no significant difference in levels of cardiac function parameters,serum contents of angiogenesis indexes and inflammatory factors between the 2 groups(P>0.05).14 d after treatment,levels of LVEF and SV in the observation group were higher than those in the control group.Serum contents of VEGF and bFGF in the observation group were higher than those in the control group.Contents of TNF-α,PCT,IL-1β and IL-6 in the observation group were lower than those in the control group(P<0.05).Conclusion:Treatment of thrombolytic therapy and Shexiang Baoxin Pills for AMI patients can further optimize the heart function,and the specific mechanism may be related to Shexiang Baoxin Pills for angiogenesis and anti-inflammatory.
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