| 引用本文:黎建明，羊妹琴，陈伟荣.黄芪赤风汤合地黄饮子化裁修复缺血性中风恢复期患者受损神经功能的临床效果[J].世界中医药,2019,(11):. |
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| 黄芪赤风汤合地黄饮子化裁修复缺血性中风恢复期患者受损神经功能的临床效果 |
| Clinical Efficacy of Modified Huagnqi Chifeng Decoction and Dihuang Decoction to Repair Damaged Nerve Function in Patients with Ischemic Stroke Convalescence |
| 投稿时间：2018-11-29 |
| DOI：10.3969/j.issn.1673-7202.2019.11.038 |
| 中文关键词: 黄芪赤风汤 地黄饮子 缺血性中风 恢复期 神经缺损程度 日常生活能力 脑血流灌注 生命质量 |
| English Keywords:Huangqi Chifeng Decoction Dihuang Decoction Ischemic stroke Convalescence Degree of nerve defect Daily living ability Cerebral perfusion Quality of life |
| 基金项目:海南省自然科学基金项目（20158233） |
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| 中文摘要: |
| 目的：探讨黄芪赤风汤合地黄饮子化裁修复缺血性中风恢复期患者受损神经功能的临床效果。方法：选取2015年1月至2017年12月儋州市人民医院收治的缺血性中风恢复期患者82例作为研究对象，按照随机数字表法分为对照组和观察组，每组41例。对照组患者给予常规西药治疗；观察组患者则在对照组基础上加用黄芪赤风汤合地黄饮子化裁内服，2组均连续用药1个月。通过神经功能缺损程度NIHSS评分、日常生活能力Barthel指数变化评价治疗前后的临床效果，并检测治疗前后患者脑血流动力学变化，评价治疗前后的生命质量。结果：观察组有效率90.24%（37/41），较对照组的73.24%（30/41）明显升高，差异有统计学意义（P<0.05）；治疗后，2组患者的神经功能、日常生活能力、脑血流动力学指标、生命质量均较治疗前有所改善，差异有统计学意义（P<0.05），NIHSS评分明显降低，日常生活能力Barthel指数、脑血流动力学指标大脑后动脉（PCA）、大脑前动脉（ACA）、大脑中动脉（MCA）、基底动脉（BA）水平及生命质量SS-QOL评分则均较治疗前有所上升。且随着时间推移，生命质量SS-QOL评分逐渐升高，差异有统计学意义（P<0.05），治疗后以观察组患者的变化程度更为明显，差异有统计学意义（P<0.05）。对照组治疗过程中的不良反应发生率为19.51%，显著高于观察组的不良反应发生率7.31%，差异有统计学意义（P<0.05）。结论：黄芪赤风汤合地黄饮子化裁有利于修复受损的神经功能，提高日常生活能力及生命质量，且用药安全可靠。 |
| English Summary: |
| To explore clinical efficacy of modified Huangqi Chifeng Decoction and Dihuang Decoction to repair damaged nerve function in patients with ischemic stroke convalescence.Methods:A total of 82 patients with ischemic stroke convalescence who were treated in Danzhou People's Hospital from January 2015 to December 2017 were selected as subjects，and they were divided into control group(n=41)and observation group(n=41)by using the random number table.Patients in the control group were treated with conventional western medicine.Patients in the observation group were added with modified Huangqi Chifeng Decoction and Dihuang Decoction orally on the treatment basis of the control group.Continuous medication for 1 month was 1 course of treatment in the 2 groups.The clinical efficacy before and after the treatment was evaluated by changes of NIHSS score and Barthel indexes of daily living ability.Changes of cerebral hemodynamics before and after the treatment were detected，and the quality of life before and after the treatment was evaluated.Results:Effective rate in the observation group was 90.24%(37/41)，which was significantly higher than 73.24%(30/41)in the control group(P<0.05).After the treatment，the nerve function，daily living ability，cerebral hemodynamic index and quality of life of patients in the 2 groups were improved compared to those before the treatment(P<0.05).The NIHSS score was decreased significantly.The Barthel index of daily living ability，levels of cerebral hemodynamic indexes PCA，ACA，MCA and BA，and the quality of life SS-QOL scores were all higher than those before the treatment.And the quality of life SS-QOL scores were gradually increased over time(P<0.05).After the treatment between the 2 groups，the changes of patients were more significant in the observation group(P<0.05).The incidence of adverse reactions in the control group during the treatment was 19.51%，which was significantly higher than the incidence of adverse reactions(7.31%)in the observation group(P<0.05).Conclusion:Modified Huangqi Chifeng Decoction and Dihuang Decoction is conducive to repair damaged nerve function，and improve daily living ability and the quality of life，and the medication is safe and reliable. |
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