| 引用本文:蒙玉娇1,2，陈朝霞1，王燕1，赵京霞1，底婷婷1，张金超1，林燕1，李萍1.慢性皮肤溃疡间充质干细胞治疗及中医药调节作用的研究进展[J].世界中医药,2019,(11):. |
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| 慢性皮肤溃疡间充质干细胞治疗及中医药调节作用的研究进展 |
| Research Progress Study on Mesenchymal Stem Cells Treatment on Chronic Skin Ulcer and Regulation of Traditional Chinese Medicine |
| 投稿时间：2018-12-27 |
| DOI：10.3969/j.issn.1673-7202.2019.11.060 |
| 中文关键词: 慢性皮肤溃疡 创面愈合 间充质干细胞 旁分泌/自分泌 多项分化 中医药 疗效 综述 |
| English Keywords:Chronic skin ulcer Wound healing MSCs Paracrine/autocrine Differentiation Traditional Chinese medicine Efficacy Review |
| 基金项目:国家自然科学基金项目(81774328) |
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| 摘要点击次数: 498 |
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| 中文摘要: |
| 慢性皮肤溃疡是外科常见病及多发病,治疗周期长且临床治疗效果不理想,寻求有效的治疗药物和方法是研究热点。间充质干细胞由于低免疫原性、多项分化潜能、来源广泛等优势,其通过旁分泌/自分泌效应和向类皮细胞分化等功能参与创面修复的多个环节,为促进难愈性创面的愈合提供了新的手段,在临床得到广泛应用和研究。作者对间充质干细胞在慢性皮肤溃疡创面愈合中的作用及中医药的调节功能进行综述,为临床和基础研究提供证据。 |
| English Summary: |
| Chronic skin ulcer is a common and frequently-occurring disease.The treatment period is long and the clinical treatment effect is not ideal.It is a research hotspot to seek effective therapeutic drugs and methods.Mesenchymal stem cells(MSCs)participate in multiple aspects of wound repair through the functions of low immunogenicity，multiple differentiation potentials，and wide sources，etc.，through the functions of paracrine/autocrine effect and differentiation to epithelial cells，in order to promote refractory wounds.The healing provides a new means of clinical application and research.The authors reviewed the role of MSCs in the healing of chronic skin ulcer wounds and the regulatory functions of Traditional Chinese Medicine，providing evidence for clinical and basic research. |
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