| 引用本文:周岩，李莹，张法英，田乃菊.复方丹参汤辅助氯吡格雷治疗冠心病的血流变、血流动力学与心功能观察[J].世界中医药,2019,(12):. |
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| 复方丹参汤辅助氯吡格雷治疗冠心病的血流变、血流动力学与心功能观察 |
| Observation on Blood Rheology, Hemodynamics and Cardiac Function in Coronary Heart Disease Patients Treated With Compound Salvia Miltiorrhiza Decoction and Clopidogrel |
| 投稿时间：2019-01-30 |
| DOI：10.3969/j.issn.1673-7202.2019.12.032 |
| 中文关键词: 氯吡格雷 复方丹参汤 冠心病 血流变 血流动力学 心功能 |
| English Keywords:Clopidogrel Compound Salvia Miltiorrhiza Decoction Coronary heart disease Blood rheology Hemodynamics Cardiac function |
| 基金项目:北京中医药科技发展资金青年研究项目(QN2015-103) |
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| 中文摘要: |
| 目的：临床观察复方丹参汤，辅助氯吡格雷治疗冠心病的血流变、血流动力学与心功能。方法：选取2016年1月至2017年12月朝阳区中医医院收治的冠心病患者90例作为研究对象，按照不同治疗方式分为对照组和观察组，每组45例。服用药物期间，给予对照组患者单纯使用氯吡格雷；在此基础上额外采用复方丹参汤作为辅助治疗给予观察组患者。记录下对照组与观察组患者的纤维蛋白含量、全血高切黏度、全血低切黏度、以及血浆比黏度，比较血流变的区别。检测治疗前后的动力学指标，包括红细胞沉降率（ESR）、红细胞压积（HCT）、纤维蛋白原（Fb）、血浆比黏度(Np)、全血黏度(Nbl)、以及高切变率下全血黏度(Nbh)。观察和记录对照组与观察组患者治疗后第1天，第7天和第14天的左室功能（LVEF）、左心室收缩末期容积（LVESV）和左心室舒张末压（LVEDP）的变化幅度。结果：治疗后血流变、血流动力学、以及心功能观察研究比较后，发现联合使用自拟复方参汤与氯吡格雷在治疗冠心病的过程中，优势明显高于单纯使用，差异有统计学意义(P<0.05)。结论：复方丹参汤比单纯使用氯吡格雷疗效显著，血液恢复时间更短，见效更快，血流变、血流动力学、均有明显优势，值得临床广泛应用。 |
| English Summary: |
| To observe the clinical effects on blood rheology, hemodynamics and cardiac function in coronary heart disease patients who were treated with Compound Salvia Miltiorrhiza Decoction and Clopidogrel.Methods:From January 2016 to December 2017, 90 patients with coronary heart disease were selected in Chaoyang District Traditional Chinese Medicine Hospital.According to the different methods, they were randomly divided into an observation group(n=45)and a control group(n=45).The patients in the control group were given Clopidogrel while based on this additional the patients in the observation group were treated with Compound Salvia Miltiorrhiza Decoction as adjuvant therapy.The fibrin content, whole blood high shear viscosity, whole blood low shear viscosity and plasma specific viscosity and differences of blood rheology were compared and recorded between the 2 groups.The dynamic parameters before and after treatment were detected, including erythrocyte sedimentation rate(ESR), hematocrit(HCT), fibrinogen(FB), np, nbl, and nbh.The changes of left ventricular function(LVEF), left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic pressure(LVEDP)in the control group and observation group were observed and recorded at 1, 7 and 14 days after treatment.Results:After the observation and comparison of blood rheology, hemodynamics and cardiac function, the advantage of Compound Salvia Miltiorrhiza Decoction and Clopidogrel were significantly higher than single use for treatment of coronary heart disease(P<0.05).Conclusion:When compared with Clopidogrel alone, Compound Salvia Miltiorrhiza Decoction has the advantages of obvious curative effect, shorter blood recovery time, faster effect, better blood rheology and hemodynamics.It is worthy of extensive clinical application. |
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