This paper introduced Professor Xu Ling's clinical experience in the differentiation and treatment of cold-heat complicated insomnia in cancer patients.Such insomnia is mainly induced by the consequences of the imbalance of yin and yang, including the incoordination between the spleen and the stomach, the disharmony between water and fire, the imbalance between heart-yang and kidney-yin as well as five minds transforming into fire.Moreover, the toxic and side effects caused by the chemotherapy as well as the targeted therapy could have impacts on the cold-heat complicated insomnia.Based on the central idea of “harmony”, the treatment for such insomnia is to balance yin and yang, together with using cold combined with hot medicines, for realizing the communications between external and internal sides.In clinic, it should pay attention to adjusting the work time and the rest time, conforming to the nature, achieving the balance through the self-harmony of yin and yang, and thus be in the healthy and vigorous state.