| 引用本文:黄玮，张琪，朱月琴，曹琰，刘产明.振元复脉颗粒对慢性心律失常模型大鼠的疗效及其部分机制研究[J].世界中医药,2020,(02):. |
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| 振元复脉颗粒对慢性心律失常模型大鼠的疗效及其部分机制研究 |
| Study on Efficacy and Part of the Mechanism of Zhenyuan Fumai Granules in Chronic Arrhythmia Model Rats |
| 投稿时间：2019-06-15 |
| DOI：10.3969/j.issn.1673-7202.2020.02.020 |
| 中文关键词: 心律失常 振元复脉颗粒 SOD MDA Na+-K+-ATP酶 PI3K-AKT通路 心肌凋亡 |
| English Keywords:Arrhythmia Zhenyuan Fumai Granules SOD MDA Na+-K+-ATPase PI3K-AKT pathway Myocardial apoptosis |
| 基金项目:常州市科技计划指导性项目(2017333);常州市孟河医派百人传承培养工程项目 |
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| 中文摘要: |
| 目的:探讨振元复脉颗粒治疗慢性心律失常模型大鼠的可能机制。方法:将60只SD大鼠随机分为空白组(10只)及造模组(50只),造模组大鼠接受尾静脉注射氯化钡溶液制备心律失常模型,将46只成模大叔数字随机分为模型组及干预组，每组23只。其中干预组大鼠利用振元复脉颗粒灌胃,模型组大鼠接受等体积生理盐水灌胃,均干预4周。比较各组大鼠心电图指标,外周血SOD、MDA、心脏组织Na+-K+-ATP、心脏组织PI3K、AKT、p-AKT浓度变化。结果:与模型组比较,振元复脉颗粒可明显缩短模型鼠心律失常持续时间(P<0.05);下降外周血MDA、Bax水平;上调SOD、PI3K、p-Akt、Bcl-2水平及Na+-K+-ATP酶活性,差异有统计学意义(P<0.05)。结论:振元复脉颗粒可明显对抗心率失常,具有保护心肌组织的作用,其作用机制可能与抗氧自由基、抑制心肌细胞凋亡有关。 |
| English Summary: |
| To explore the possible mechanism of Zhenyuan Fumai Granules in the treatment of chronic arrhythmia model rats.Methods:A total of 60 SD rats were randomly divided into blank group(n=10)and modeling group(n=50).The modeling group was injected with barium chloride solution through tail vein to establish arrhythmia model.A total of 46 model rats were randomly divided into model group(n=23)and intervention group(n=23).Among them, the rats in the intervention group were given intragastric administration of Zhenyuan Fumai Granules for 4 weeks, and the rats in the model group were given intragastric administration of the same volume of normal saline for 4 weeks.ECG indexes, SOD and MDA in peripheral blood, Na+-K+-ATP in heart tissue, as well as concentration changes of PI3K, AKT and p-AKT in heart tissue were compared in each group.Results:1)Compared with the model group, Zhenyuan Fumai Granules could significantly shorten the duration of arrhythmia(P<0.05), decrease the levels of MDA and Bax in peripheral blood, and increase the levels of SOD, PI3K, p-Akt and Bcl-2 as well as Na+-K+-ATP activity.The differences were statistically significant(P<0.05).Conclusion:Zhenyuan Fumai Granules can obviously antagonize arrhythmia and protect myocardial tissue, and its mechanism may be related to anti-oxygen free radicals and inhibition of cardiomyocyte apoptosis. |
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