| 引用本文:杜泓森1,3，史金玉3，王帅3，安莹3，靳会会3，贾静芸3，赵海滨2.柴胡加龙骨牡蛎汤对急性心肌梗死合并焦虑小鼠血清ACTH及CORT的影响[J].世界中医药,2020,(02):. |
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| 柴胡加龙骨牡蛎汤对急性心肌梗死合并焦虑小鼠血清ACTH及CORT的影响 |
| Effects of Chaihu Plus Longgu Muli Decoction on Serum ACTH and CORT in Mice with Acute Myocardial Infarction and Anxiety |
| 投稿时间：2019-08-16 |
| DOI：10.3969/j.issn.1673-7202.2020.02.021 |
| 中文关键词: 柴胡加龙骨牡蛎汤 AMI合并焦虑 小鼠 血清 疗效 机制 ACTH CORT |
| English Keywords:Chaihu Plus Longgu Muli Decoction AMI with anxiety Mice Serum Efficacy Mechanism ACTH CORT |
| 基金项目:北京市科技计划课题(Z161100000516136)——首都特色—从“双心”探析冠心病合并焦虑状态及柴胡加龙骨牡蛎汤的干预效应;北京中医药大学自主课题(2018-JYBZZ-JS167)——基于NF-κB/COX-2交叉对话探讨焦虑对心梗后BMSCs循环的影响及双心同治的干预效应 |
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| 中文摘要: |
| 目的:观察柴胡加龙骨牡蛎汤对AMI合并焦虑小鼠血清ACTH及CORT的影响。方法:将30只小鼠随机分为假手术组、AMI组、焦虑组、AMI+焦虑组、中药组,每组6只,以冠脉结扎法合并空瓶刺激法制作复合模型,予柴胡加龙骨牡蛎汤干预14 d。造模结束后,予行为学及心脏彩超检测,后处死取各组血清检测ACTH及CORT含量。结果:与假手术组比较,AMI组小鼠LVEF和LVFS明显降低,LVEDd及LVESd值明显增加;AMI组及焦虑组小鼠水平和垂直运动得分均降低,开放臂进入次数和停留时间均减少;焦虑组ACTH和CORT含量增加;AMI组仅ACTH含量增多。与AMI+焦虑组比较,AMI组、焦虑组及中药组的LVEF、LVFS升高,LVEDd值明显较低;水平和垂直运动得分均升高;血清ACTH和CORT含量均降低。LVESd值仅AMI组及焦虑组降低;AMI组及中药组的OE%增加、OT%延长,焦虑组仅OT%延长。结论:柴胡加龙骨牡蛎汤抗焦虑、改善AMI预后的疗效机制可能与抑制ACTH和CORT含量的升高有关。 |
| English Summary: |
| To observe effects of Chaihu Plus Longgu Muli Decoction on serum ACTH and CORT in mice with acute myocardial infarction(AMI)complicated with anxiety.Methods:Thirty mice were randomly divided into sham operation group, AMI group, anxiety group, AMI+anxiety group and traditional Chinese medicine group(n=6).The compound model was made through coronary artery ligature combined with empty bottle stimulation and intervened by Chaihu Plus Longgu Muli Decoction for 14 d.After the establishment of the model, behavioral and Echocardiography detection was conducted.After execution, contents of ACTH and CORT in the serum in each group were detected.Results:Compared with the sham operation group, LVEF and LVFS in the AMI group were significantly decreased, while LVEDd and LVESd were significantly increased.Scores of horizontal and vertical movements in the AMI group and the anxiety group were decreased, while open arm entry times and residence time were decreased.The ACTH and CORT contents were increased in the anxiety group, and only the ACTH content was increased in the AMI group.Compared with the AMI+anxiety group, the LVEF and LVFS in the AMI, anxiety and traditional Chinese medicine groups were significantly increased, while the LVEDd values were significantly decreased; the horizontal and vertical movement scores were increased; and the serum ACTH and CORT contents were decreased.The LVESd values were decreased only in the AMI and anxiety groups.OE% was increased and OT% was prolonged in the AMI and traditional Chinese medicine groups, and only OT% was prolonged in the anxiety group.Conclusion:The therapeutic mechanism of Chaihu Plus Longgu Muli Decoction in anti-anxiety and improving the prognosis of AMI may be related to the inhibition of the increase of ACTH and CORT contents. |
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