To observe the clinical effect of modified Danggui Sini Plus Wuyu Shengjiang Decoction combined with desloratadine tablet in the treatment of chronic urticaria patients and its influence on serum IgE, IL-13, TSP-1 and D-dimer levels.Methods:A total of 110 patients with chronic urticaria admitted to the outpatient department of dermatology of Shenyang Seventh People's Hospital were selected as the research objects, and were divided into a control group(n=55 cases)and an observation group(n=55 cases)by random number table method.Patients in the control group were given desloratadine tablets orally; The observation group was treated with modified Danggui Sini Plus Wuyu Shengjiang Decoction combined with desloratadine tablet, and the 2 groups were treated for 1 month as one treatment course.The clinical efficacy of the 2 groups was compared by observing the urticaria attack situation and the change of TCM syndrome integral of the 2 groups.The quality of life was evaluated by dermatology life quality index(dermatology life quality index, DLQI)scale before and after treatment.The serum total IgE, IL-13,TSP-1 and D-dimer levels were monitored, and the recurrence rate of cured patients follow-up for half a year was analyzed and adverse reactions in the treatment process were counted.Results:The clinical effective rate of 74.55% in the control group was significantly lower than 90.91% in the observation group(P<0.05).The patients in the observation group showed more obvious improvement in the incidence of air mass，and the number, maximum diameter, frequency and duration of air mass were significantly decreased compared with those in the control group(P<0.05).TCM syndrome score and DLQI score of quality of life were significantly lower than those of the control group(P<0.05).The serum total IgE level showed a significant downward trend(P<0.05), and was significantly lower in the observation group than in the control group(P<0.05).The serum levels of IL-13 and D-dimer in the observation group were decreased than those in the control group(P<0.05), while the levels of TSP-1 were increased than those in the control group(P<0.05).Follow-up for half a year, the recurrence rate of 12.5% in the observation group was significantly lower than 30% in the control group(P<0.05).The rate of adverse reactions in the treatment of patients in the observation group was 7.27%, which was lower than 21.82% in the control group(P<0.05).Conclusion:The treatment plan of treating chronic urticaria patients with modified Danggui Sini Plus Wuyu Shengjiang Decoction combined with desloratadine tablet is to reduce the air mass attack rate of the patients with chronic urticaria, relieve the clinical symptoms and improve quality of life.Its effect may be related to adjusting the serum IL-13, TSP-1, D-dimer levels to reduce the abnormal secretion of IgE, improve the way such as vascular permeability and the body's blood coagulation state, which is worthy of clinical promotion.