To explore short-term efficacy of Buzhong Yiqi Decoction combined with XELOX regimen in the treatment of advanced gastric cancer, and its effects on long-term survival.Methods:A total of 90 cases of advanced gastric cancer patients treated in Lishui People's Hospital during February 2013 to February 2016 were selected as study objects and divided into control group and observation group by random number table method, with 45 cases in each group.Patients in the control group received XELOX regimen chemotherapy, and those in the observation group received XELOX regimen chemotherapy+Buzhong Yiqi Decoction.Short-term overall efficacy, contents of tumor markers and medication safety were compared between the 2 groups.The patients were followed up for 2 years and their survival was recorded.Results:After the treatment, the effective rate and disease control rate in the observation group were higher than those in the control group(P<0.05); serum contents of CA19-9, CA72-4, CA50 and SF were lower than those in the control group(P<0.05).There was no significant difference in incidences of adverse drug reactions such as rash, nausea and vomiting, liver function damage, bone marrow suppression and infection between the 2 groups during the treatment(P>0.05).Follow-up showed that the 1-year survival rate in the observation group was higher than that in the control group(P<0.05), and there was no significant difference in 2-year survival rate between the 2 groups(P>0.05).Conclusion:The combination of XELOX chemotherapy and Buzhong Yiqi Decoction is helpful to improve the short-term efficacy and prolong the long-term survival rate in patients with advanced gastric cancer, and has good medication safety.