| 引用本文:孟硕，彭勍，张鹏，刘建勋.麻荆颗粒质量标准研究[J].世界中医药,2020,(05):. |
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| 麻荆颗粒质量标准研究 |
| Study on Quality Standard of Majing Granule |
| 投稿时间：2018-11-08 |
| DOI：10.3969/j.issn.1673-7202.2020.05.012 |
| 中文关键词: 麻荆颗粒 麻黄 黄芩 甘草 指纹图谱 高效液相 提取工艺 质量标准 |
| English Keywords:Majing Granule Herba Ephedrae Radix Scutellariae Radix Glycyrrhizae Fingerprint HPLC Extraction process Quality standard |
| 基金项目:北京市十病十药研发专项（Z171100001717007） |
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| 中文摘要: |
| 目的：建立麻荆颗粒的质量标准。方法：应用高效液相色谱法测定麻荆颗粒中麻黄碱、黄芩苷、甘草苷的含量，建立麻荆颗粒的高效液相指纹图谱。结果：盐酸麻黄碱在0.289 2～2.892 0 μg范围内呈良好的线性关系（r=0.999 9），黄芩苷在0.208 0～2.080 0 μg范围内呈良好的线性关系（r=0.999 9），甘草苷在0.192 0～1.920 0 μg范围内呈良好的线性关系（r=0.999 9）。初步建立了麻荆颗粒颗粒的高效液相色谱指纹图谱，相似度均在0.96以上，10批次样品中确定了12个共有峰，并指认其中5个共有峰。结论：本方法稳定、准确可靠，能有效的为麻荆颗粒质量控制提供依据。 |
| English Summary: |
| To establish the quality standard of Majing Granule.Methods:The contents of ephedrine，baicalin and glycyrrhizic glycoside were measured by HPLC.The HPLC fingerprint of Majing Granules was established.Results:There was a good linear relationship of ephedrine hydrochloride in the range of 0.289 2～2.892 0 μg(r=0.999 9).There was a good linear relationship of baicalin in the range of 0.208 0~2.080 0 μg(r=0.999 9).There was a good linear relationship of liquiritin in the range of 0.192 0~1.920 0 μg(r=0.999 9).The HPLC fingerprint of Majing granules was preliminarily established，and the similarity was above 0.96.A total of 12 common peaks were identified in 10 batches of samples，and 5 of them were identified.Conclusion:This method is stable，accurate and reliable，which can provide the basis for the quality control of Majing Granule. |
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