脂肪肝严重程度与中医证型关系的Meta分析
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国家自然科学基金面上项目(81473667)


The Relationship Between the Fatty Liver Severity and the TCM Syndromes:A Meta-Analysis
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    摘要:

    目的:分析脂肪肝轻中重度分型与中医证型分型之间的关系。方法:计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据知识服务平台、中国生物医学文献数据库(CBM)。采用R-3.5.1软件进行Meta分析,以率、95%可信区间(CI)表达效应值。结果:共纳入12项观察性研究,样本量总计3 379例。Meta分析结果:肝郁脾虚型中,轻度脂肪肝高于中、重度脂肪肝;痰湿内阻中,中度脂肪肝高于轻、重度脂肪肝;湿热内蕴中,轻度脂肪肝高于中、重度脂肪肝;痰瘀互结中,重度脂肪肝高于轻、中度脂肪肝;肝肾亏虚型无统计学差异。结论:基于目前证据,轻度脂肪肝以肝郁脾虚型及湿热内蕴型为主,中度脂肪肝以痰湿内阻型为主,重度脂肪肝以痰瘀互结型为主,肝肾亏虚型无统计学差异,其在脂肪肝分型中的分布情况需要更大的样本进一步验证。

    Abstract:

    To analyze the relationship between the mild,moderate and severe fatty liver and the TCM syndromes.Methods:The database of CNKI,VIP,Wanfang Data,CBM were retrieved.Meta-analysis was conducted with R-3.5.1 software having rate and 95% confidence interval(CI)as effect size.Results A total of 12 observation studies were included,involving 3 379 total sample cases.Meta-analysis showed that in syndrome of stagnation of liver qi and spleen deficiency type,the mild was higher than moderate or severe; Among the syndrome of internal retention of damp-heat,mild was higher than moderate or severe; Among the syndrome of intermin-gled phlegm and blood stasis,severe was higher than mild and moderate; There was no statistical difference in the syndrome of deficiency of both liver and kidney type.Conclusion:Based on current evidence,light fatty liver was the stagnation and blockade of phlegm-damp type and internal retention of damp-heat type,and the moderate fatty liver was syndrome of stagnation and blockade of phlegm-damp type.Severe fatty liver was mainly the syndrome of intermin-gled phlegm and the syndrome of blood stasis type and syndrome of deficiency of both liver and kidney type,with no statistical difference.

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王楠,王阳,袁慧琴,李小圳,刘磊,宋志超,陈正光.脂肪肝严重程度与中医证型关系的Meta分析[J].世界中医药,2020,(05).

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  • 收稿日期:2018-11-16
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  • 在线发布日期: 2020-04-10
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