世界中医药

目的：研究观察小儿宝泰康颗粒治疗小儿急性上呼吸道感染的临床疗效及安全性评价。方法：选取2018年1月至2019年1月山东省立医院儿科门诊收治的急性上呼吸道感染患儿86例作为研究对象，按照就诊先后顺序编号分为对照组和观察组，每组43例。对照组给予小儿豉翘清热颗粒治疗，观察组给予小儿宝泰康颗粒治疗。对2组患儿的临床疗效、症状消退时间、血清炎性反应因子水平、不良反应发生率等进行统计比较。结果：治疗后观察组总有效率高于对照组，差异有统计学意义(P<0.05)，且观察组痊愈率高于对照组，差异有统计学意义(P<0.05)，显效率低于对照组，差异有统计学意义(P<0.05)；有效率2组较为相近，差异无统计学意义(P>0.05)，无效率低于对照组，差异有统计学意义(P<0.05)。治疗后观察组发热、咳嗽、鼻塞流涕、咽喉肿痛、脘腹胀满、食欲不振等症状消退时间均短于对照组，组间比较，差异有统计学意义(P<0.05)。治疗后2组患儿的血清白细胞介素-6(IL-6)、血清白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均有显著降低，差异有统计学意义(P<0.05)，且观察组各项指标水平均低于对照组，差异有统计学意义(P<0.05)。对照组发生水样便腹泻2例，腹痛1例，观察组未出现不良反应，组间比较，差异无统计学意义(P>0.05)。结论：小儿宝泰康颗粒治疗小儿急性上呼吸道感染的临床疗效显著，能够缩短患儿的症状消退时间，降低患儿自身的炎性反应水平，治疗安全性良好，值得临床推荐。

English Summary:

To study and observe the clinical efficacy and safety evaluation of Xiaoer Baotaikang Granules in the treatment of acute upper respiratory tract infection in children.Methods:A total of 86 children with acute upper respiratory tract infection admitted to our pediatric clinic from January 2018 to January 2019 were randomly divided into an observation group and a control group,with 43 cases in each group.The control group was treated with Xiaoer Guqiao Qingre Granules,while the observation group was treated with Xiaoer Baotaikang Granules.Clinical efficacy,symptoms subsidence time,serum levels of inflammatory factors and incidence of adverse reactions of the 2 groups were compared.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05),and the cure rate of the observation group was higher than that of the control group(P<0.05),and the significant efficiency was lower than that of the control group(P>0.05).The inefficiency was lower than that of the control group(P<0.05).After treatment,the symptoms disappearance time of fever,cough,nasal obstruction,runny nose and sore throat,abdominal distension and loss of appetite in the observation group were shorter than those in the control group and there were statistical difference between the 2 groups(P<0.05).After treatment,the levels of serum interleukin-6(IL-6),interleukin-18(IL-18),tumor necrosis factor-a(TNF-a)and C-reactive protein(CRP)in the 2 groups were significantly decreased(P<0.05),and the levels of each index in the observation group were lower than those in the control group(P<0.05).There were 2 cases of watery stool diarrhea and 1 case of abdominal pain in the control group.No adverse reactions occurred in the observation group.There were no statistical difference between the 2 groups(P<0.05).Conclusion:Xiaoer Baotaikang Granules is effective in the treatment of acute upper respiratory tract infection in children.It can shorten the time of symptoms subsidence,reduce the level of inflammation reaction in child patients,and has good therapeutic safety.It is worthy of clinical recommendation.

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