To observe the therapeutic effects of Qinggan Jieyu and Jianpi Bushen method in patients (liver fire syndrome) with chronic renal failure (CRF) and hypertension.Methods:A total of 90 patients with CRF and hypertension who were admitted to the Jingdongyumei Hospital from June 2016 to June 2018 were randomly divided into an observation group and a control group by random number table method, with 45 cases in each group.The control group was treated with oral nifedipine controlled-release tablets.The observation group was treated with Qing Ganjieyu and Jianpi Bushen Decoction on the basis of the control group, and all patients were treated for 3 courses, 4 weeks fore per course.Before and after treatment, the traditional Chinese medicine syndrome scores, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared between 2 groups.The renal function indicators including urea nitrogen (BUN), serum creatinine (Scr), 24 h urine protein quantitation (24 hPRO) were compared between the 2 groups before and after treatment.And the incidence of adverse reactions in the 2 groups during treatment were recorded.Results:There was no significant difference between the observation group and the control group before treatment in TCM syndrome scores, SBP, DBP, BUN, Scr and 24 hPRO and the difference was statistically significant (P>0.05), while the results in observation group was all lower than those of the control group after treatment, and the difference was statistically significant (P<0.05).All the results in 2 groups were significantly lower than those before treatment (P<0.05).The rank distribution of difference in clinical efficacy between 2 groups was statistically significant (P<0.05), and the total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The incidence of adverse reactions in the study group and the control group were 2.22% and 6.67%, respectively, and there was no significant difference between 2 groups, the difference was statistically significant (P>0.05).Conclusion:Adjuvant therapy of Qinggan Jieyu and Jianpi Bushen method on patients (liver fire syndrome) with CRF and hypertension is effective, which could control blood pressure well, improve renal function and reduce the incidence of adverse reactions.