Ulcerative colitis is mainly caused by the interaction of many factors,such as heredity,environment,infection,intestinal mucosal barrier function defect etc. The mechanism of Riclix Sophoteflavescentis and its compound in the prevention and treatment of ulcerative colitis mainly includes regulating the imbalance of immune cells,regulating the expression of cytokines and inflammatory mediators,affecting signal transduction pathway,antioxidation,regulating apoptosis,repairing intestinal tissue etc. Its related research not only provides theoretical basis and experimental data support for clinical drug use,but also plays an important role in exploring the treatment of ulcerative colitis with traditional Chinese medicine.