To investigate the effects of oral administration of traditional Chinese medicine combined with external application of Zhongtongxiao on acute gouty arthritis of damp-heat and stasis type, and its effects on erythrocyte sedimentation rate (ESR), Interleukin-1 β (IL-1β) and oxidative stress.Methods:From June 2017 to October 2019, a total of 120 patients with acute gouty arthritis who were admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province were divided into a control group and an observation group, with 60 cases in each group, by random number table.The control group was treated with Western medicine, and the observation group was given traditional Chinese medicine orally combined with external application of Zhongtongxiao.Both groups were treated continuously for 14 days.The clinical efficacy of the 2 groups was counted; joint function and joint pain scores, serum uric acid (UA), and ESR levels were compared between the 2 groups, and the levels of inflammatory factors and oxidative stress factors were detected and compared in the 2 groups before and after treatment.Results:The total effective rate in the observation group was higher than that in the control group (96.67% vs 78.33%, P<0.05).After treatment, the joint function grading scores, joint tenderness, joint swelling, and joint pain scores at rest were reduced in the w groups, and the observation group was lower than the control group (P<0.05).After treatment, the ESR, IL-1β, IL-6, and UA of the 2 groups decreased, and the observation group was lower than the control group (P<0.05).After treatment, the serum 8OHdG and LPO in the 2 groups decreased, and the observation group was lower than the control group; the TAOC increased in the 2 groups, and the observation group was higher than the control group (P<0.05).Conclusion:Oral administration of Chinese medicine combined with external application of Zhongtongxiao can effectively relieve pain, improve UA, ESR levels and joint function in patients with acute gouty arthritis, which may be related to reducing the body's inflammatory response and regulating oxidative stress.