To investigate the effects of Shexiang Baoxin Pills combined with isosorbide mononitrate on blood lipids and blood rheology in patients with coronary heart disease and its safety.Methods:A total of 143 cases patients with coronary heart disease in Baoding First Central Hospital from January 2014 to December 2016 were selected as study objects and were divided randomly into a test group (n=72) and a control group (n=71).The control group was treated with isosorbide mononitrate(1 tablet·time-1, 3 times·d-1), and the test group was treated with Shexiang Baoxin Pill (1 pill·time-1, 3 times·d-1) on the basis of control group.The 2 groups were treated consecutively for 2 months.The clinical efficacy of 2 groups were compared after treatment; the occurrence of angina pectoris of 2 groups was counted; the total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and hemorheology indexes of 2 groups were detected and compared before and after treatment; the incidence rates of adverse reactions of 2 groups were compared.Results:After treatment, the clinical efficacy of test group was 95.83%, which was higher than 69.01% in the control group (P<0.01); Ccompared with that before treatment, the frequency of angina pectoris in 2 groups decreased, and the occurrence duration of 2 groups shortened, and there was obvious difference between 2 groups (P<0.01); compared with those before treatment, the serum TC, TG, LDL-C levels of 2 groups decreased after treatment, and test group was lower than control group; the serum HDL-C levels of 2 groups increased after treatment, and test group was higher than control group (P<0.05 or P<0.01); compared with those before treatment, the whole blood viscosity, plasma viscosity, fibrinogen, hematocrit, erythrocyte sedimentation of 2 groups decreased after treatment, and test group was lower than control group (P<0.05 or P<0.01); there were no obvious difference between 2 groups on the incidence rate of adverse reactions (P>0.05).Conclusion:Shexiang Baoxin Pills combined with isosorbide mononitrate tablets have significant curative effects on coronary heart disease, which can effectively improve the angina pectoris and blood lipid levels of patients, and improve their blood rheology, and the combination of 2 drugs has a better effect.