Recent studies have shown that ecological imbalance of intestinal microbiota,inflammation and impaired mucosal immune function are important factors for the occurrence and development of NAFLD.This paper reviews the research progress in the treatment of non-alcoholic fatty liver by regulating intestinal microbiota,such as probiotics,antibiotics,adhesion molecules,intestinal bacteria transplantation,and the application of traditional Chinese medicine in non-alcoholic fatty liver.The authors believes that the regulation of intestinal microbiota is one of the important strategies and targets for the treatment of non-alcoholic fatty liver and has a good prospect.