| 引用本文:郑舒月1，段桦1，彭艳梅3，张静怡1，申文1，孙晨耀1，张旭1，谭可欣1，姜雪娇1，崔慧娟2.中医药治疗表皮生长因子受体抑制剂相关皮疹的系统性评价[J].世界中医药,2020,(08):. |
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| 中医药治疗表皮生长因子受体抑制剂相关皮疹的系统性评价 |
| Effects of Traditional Chinese medicine on Rash Caused by Epidermal Growth Factor Receptor Inhibitors:a Meta-Analysis |
| 投稿时间：2019-12-23 |
| DOI：10.3969/j.issn.1673-7202.2020.08.010 |
| 中文关键词: 表皮生长因子受体抑制剂 皮疹 中医药 Meta分析 |
| English Keywords:Epidermal growth factor receptor inhibitors Rash Traditional Chinese medicine Meta-analysis |
| 基金项目:国家自然科学基金项目（81873396）——基于PLA2G4A基因的IL-6-STAT3信号通路调控的“止痒平肤液”对靶向药相关皮疹疗效的分子机制研究；首都卫生发展科研专项项目（首发2018-2-4065）——外用中药“止痒平肤液”治疗中重度靶向药相关皮疹的前瞻随机对照临床研究 |
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| 目的：评价中医药治疗表皮生长因子受体抑制剂（EGFRIs）相关皮疹的疗效及安全性。方法：在外文Web of Science、PubMed、Cochrane Library和维普数据库（VIP）、中国学术期刊全文数据库（CNKI）、万方数据库中检索从创建以来至2018年3月关于中医药治疗EGFRIs相关皮疹的随机对照试验，并手工检索补充相应文献。由研究人员对文献进行筛选和数据提取，并用Rev Man5.3进行异质性检验、敏感性分析和Meta分析。结果：纳入21项研究，共1 394例肿瘤患者，Meta分析结果显示中医药治疗EGFRIs相关皮疹的有效率、减轻皮肤瘙痒的有效率、中医症状缓解的有效率明显优于对照组（P<0.01），且中医药观察组的患者生命质量明显改善，极少出现治疗相关的不良反应。实体瘤治疗总有效率与未予中医药观察组相当（P>0.05）。结论：中医药治疗可明显缓解EGFRIs相关皮疹和瘙痒，明显缓解中医证候，提高患者的生命质量，且不影响EGFRI的抗肿瘤疗效。 |
| English Summary: |
| To evaluate the efficiency and safety of Traditional Chinese medicine (TCM) on rash caused by epidermal growth factor receptor inhibitors (EGFRIs).Methods:The Web of Science, PubMed, Cochrane Library and VIP Database for Chinese Technical Periodicals (VIP), China National Knowledge Infrastructure (CNKI), Wanfang databases were searched for randomized controlled trials on the treatment of EGFRIs-related rashes from the time of creation to March 2018, and corresponding literature were manually searched to supplement.The literature and extracted data were screened by researchers, and Rev Man 5.3 was used for heterogeneity testing, sensitivity analysis, and meta-analysis.Results:Meta-analysis results showed that the effectiveness of Chinese medicine in treating EGFRIs-related rashes, the effectiveness of reducing skin itching, and the effectiveness of Chinese medicine symptom relief were significantly better than the control group (P<0.01), and the quality of life of patients in the Chinese medicine treatment group was significantly improved.There were very few treatment-related adverse reactions.The total effective rate of solid tumor treatment is comparable to the group without traditional Chinese medicine treatment (P>0.05).Conclusion:Traditional Chinese medicine treatment can significantly relieve EGFRIs-related rashes and itching, significantly relieve TCM syndromes, improve patients' quality of life, and does not affect the anti-tumor efficacy of EGFRI. |
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