| 引用本文:梁晓瑜1，张中平2，谭景斐1.基于核转录因子-κB信号通路探讨针灸四关穴治疗偏头痛的机制[J].世界中医药,2020,(08):. |
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| 基于核转录因子-κB信号通路探讨针灸四关穴治疗偏头痛的机制 |
| Mechanism of Acupuncture and Moxibustion at Siguan Point for Migraine Based on Nuclear Transcription Factor-Kappa B Signaling Pathway |
| 投稿时间：2019-09-24 |
| DOI：10.3969/j.issn.1673-7202.2020.08.024 |
| 中文关键词: 核转录因子-κB信号通路 针灸 四关穴 偏头痛 降钙素原基因相关肽 5-羟色胺 大脑血流速度 疗效 |
| English Keywords:Nuclear transcription factor-kappa B signaling pathway Acupuncture and moxibustion Siguan point Migraine Procalcitonin gene-related peptide 5-hydroxytryptamine Cerebral blood flow velocity Therapeutic effects |
| 基金项目:国家自然科学基金面上基金项目（81373571）——基于长时程增强效应升降散干预神经病理性疼痛中枢敏化的机制研究 |
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| 中文摘要: |
| 目的：基于核转录因子-κB信号通路（NF-κB）探讨针灸四关穴治疗偏头痛疗效。方法：选取2018年2月至2019年2月广州中医药大学祈福医院收治的偏头痛患者114例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组57例。对照组采用常规西药治疗，观察组在常规西药治疗的基础上加用针灸四关穴治疗，均治疗4周。比较2组症状积分、临床疗效、NF-κB信号通路及其相关指标变化。结果：治疗后2组降钙素原基因相关肽（CGRP）、VAS评分、症状持续时间、发作频率、NF-κB、环氧合酶抑制剂（COX-2）、白细胞介素-1β（IL-1β）、一氧化氮合酶（iNOS）、肿瘤坏死因子-α（TNF-α）、大脑前动脉（ACA）、大脑中动脉（MCA）、大脑后动脉（PCA）、椎动脉（VA）、基底动脉（BA）平均血流速度均较治疗前下降，差异均有统计学意义（P<0.05），而β-内啡肽（β-EP）和5-羟色胺（5-HT）均较治疗前升高，差异均有统计学意义（P<0.05），且观察组优于对照组，差异有统计学意义（P<0.05）。观察组总有效率为87.72%，高于对照组的71.93%，差异有统计学意义（P<0.05）。结论：四关穴能改善NF-κB信号通路，改善大脑动脉血流速度，从而改善偏头痛症状。 |
| English Summary: |
| To explore the efficacy of acupuncture at Siguan acupoint in the treatment of migraine based on nuclear factor-κ B signal pathway (NF-κ B).Methods:A total of 114 patients with migraine treated in Qifu Hospital of Guangzhou University of Traditional Chinese Medicine from February 2018 to February 2019 were randomly divided into a control group (n = 57) and an observation group (n = 57).The control group was treated with routine Western medicine，and the observation group was treated with acupuncture at Siguan point for 4 weeks.The symptoms，clinical efficacy，NF-κ B signal pathway and related indexes were compared between the 2 groups.Results:After treatment，procalcitonin gene-related peptide (CGRP)，VAS score，duration，seizure frequency，NF-κ B，cyclooxygenase inhibitor (COX-2)，interleukin-1 β (IL-1 β)，nitric oxide synthase (iNOS)，tumor necrosis factor-α (TNF-α)，anterior cerebral artery (ACA)，middle cerebral artery (MCA)，posterior cerebral artery (PCA)，vertebral artery (VA)，and the mean blood flow velocity of basilar artery (BA) were lower than those before treatment (P<0.05).The levels of β-endorphin (β-EP) and 5-hydroxytryptamine (5-HT) were higher than those before treatment(P<0.05)，and the observation group was better than the control group (P<0.05).The total effective rate of the observation group was 87.72%，which was higher than that of the control group (71.93%).The difference was statistically significant (P<0.05).Conclusion:Acupuncture and moxibustion at Siguan point can improve the signal pathway of NF-kappa B and the blood flow velocity of cerebral artery，so as to improve the symptoms of Migraine. |
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