| 引用本文:姜德友，李文昊，解颖，任鹏鹏，韩洁茹.嘌呤配体P2X门控离子通道型受体7及其下游分子在痛风性关节炎中作用机制的研究进展[J].世界中医药,2020,(08):. |
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| 嘌呤配体P2X门控离子通道型受体7及其下游分子在痛风性关节炎中作用机制的研究进展 |
| Progress in the Mechanism of Purinergic Receptor P2X, Ligand-gated Ion Channel 7 and its Downstream Molecules in Gouty Arthritis |
| 投稿时间：2019-03-14 |
| DOI：10.3969/j.issn.1673-7202.2020.08.028 |
| 中文关键词: 痛风性关节炎 P2X7R Nod样受体蛋白3 NEK7 IL-1β 疼痛 尿酸钠 信号通路 |
| English Keywords:Gouty arthritis P2X7R NLRP3 NEK7 IL-1β Pain Sodium urate Signaling pathway |
| 基金项目:国家自然科学基金项目（81704055）；黑龙江中医药大学校基金（201733） |
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| 中文摘要: |
| 目前随着痛风性关节炎的发病率逐年上升，对该病炎性反应及疼痛机制的研究越来越多，该病主要由尿酸盐沉积及ATP刺激P2X7R、Nod样受体蛋白3、NEK7表达诱导炎性反应递质成熟与分泌所致，但具体机制尚不明确。现对P2X7R、NLRP3、NEK7的国内外研究进展进行综述，以探讨GA炎性反应及疼痛的发病机制，为防治GA提供新思路与治疗靶点。 |
| English Summary: |
| At present,with the increasing incidence of gouty arthritis year by year,more and more studies have been done on the inflammatory reaction and pain mechanism of gouty arthritis.Scholars believe that the disease is mainly caused by the deposition of uric acid and ATP stimulating the expression of P2X7R,NLRP3 and NEK7 to induce the maturation and secretion of inflammatory factors,but the specific mechanism is still unclear.Therefore,this paper reviewed the research progress of P2X7R,NLRP3 and NEK7 at home and abroad,in order to explore the pathogenesis of inflammation and pain in GA,and to provide new ideas and therapeutic targets for the prevention and treatment of GA. |
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