To observe and analyze the clinical effects of Huoxue Jiegu Decoction combined with minimally invasive bone graft on nonunion of middle and lower tibia fracture.Methods:From January 2017 to January 2018,a total of 150 cases of nonunion of middle and lower tibial fractures were selected and retrospectively analyzed in the Second Hospital of Huangshi.According to the difference of treatment methods,they were divided into an experimental group(Huoxue Jiegu Decoction combined with minimally invasive bone graft treatment,n＝88)and a control group(minimally invasive bone graft treatment,n＝62).The degree of improvement in the clinical efficacy,hemorheology,biomechanics and the level of serum inflammatory factor IL-6,CRP and TNF-α were observed in both groups.Results:The clinical effects of the experimental group was significantly better than that of the control group.The improvement degree of hemorheology,biomechanics and serum inflammatory factor levels in the experimental group was significantly better than those of the control group and the difference is statistically significant(P<0.05).Conclusion:The clinical effects of Huoxue Jiegu Decoction combined with minimally invasive bone grafting is remarkable for the treatment of nonunion of middle and lower tibial fractures.It has a positive effects on the hemorheology of the patients,and the biomechanical level of the prognosis of patients has higher superiority.The serum levels of IL-6 TNF-α and CRP are significantly improved,which has a great significance for the treatment of nonunion of middle and lower tibial fractures.