| 引用本文:陈羽，申建国，张亮.柴胡桂枝汤在小儿肠系膜淋巴结炎（脾胃湿热证）的临床研究影响[J].世界中医药,2020,(09):. |
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| 柴胡桂枝汤在小儿肠系膜淋巴结炎（脾胃湿热证）的临床研究影响 |
| Effects of Chaihu Guizhi Decoction on Patients with Mesenteric Lymphadenitis(Dampness-heat Syndromes in Spleen and Stomach) |
| 投稿时间：2020-03-02 |
| DOI：10.3969/j.issn.1673-7202.2020.09.021 |
| 中文关键词: 小儿肠系膜淋巴结炎 柴胡桂枝汤 疼痛 PCT IL-6 IL-8 |
| English Keywords:Mesenteric lymphadenitis in child patients Chaihu Guizhi Decoction Pain PCT IL-6 IL-8 |
| 基金项目:河北省科技发展计划项目（Y-16049）；沧州市重点研发计划指导项目（17292191）——柴胡桂枝汤治疗小儿肠系膜淋巴结炎(脾胃湿热证)的临床研究 |
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| 中文摘要: |
| 目的：探讨柴胡桂枝汤对肠系膜淋巴结炎患者疼痛及血清降钙原素（PCT）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）水平的影响。方法：选取2018年7月至2019年11月沧州中西医结合医院收治的肠系膜淋巴结炎（脾胃湿热证）患儿90例作为研究对象，按照随机数字表法随机分为对照组（n=40）和观察组（n=50）。对照组给予头孢克洛混悬剂治疗，观察组在对照组的基础上加用柴胡桂枝汤治疗，比较2组临床疗效。结果：观察组总有效率（90.00%）显著高于对照组（77.50%）（P<0.05）；与治疗前比，2组中医证候积分各积分及血清PCT、IL-6、IL-8水平均降低，且观察组显著低于对照组（P<0.05）；观察组各主次症消失时间均显著短于对照组（P<0.05）；与治疗前比，治疗后2组肠系膜淋巴结纵横径均缩短，且观察组显著短于对照组（P<0.05）；观察组不良反应总发生率（6.00%）显著低于对照组（20.00%）（P<0.05）。结论：柴胡桂枝汤可有效治疗小儿肠系膜淋巴结炎，改善中医证候积分，加快症状消失时间，缓解疼痛，缩短患儿腹部肠系膜淋巴结纵横径大小，疗效显著。 |
| English Summary: |
| To investigate the effects of Chaihu Guizhi Decoction on pain and serum levels of calcitonin(PCT),interleukin-6(IL-6)and interleukin-8(IL-8)in patients with mesenteric lymphadenitis.Methods:From July 2018 to November 2019,a total of 90 children with mesenteric lymphadenitis(spleen and stomach dampness-heat syndrome)admitted to Hebei Cangzhou Hospital of Traditional Chinese and Western Medicine were selected and randomly divided into a study group(n＝50)and a control group(n＝40)according to the random number table.The control group was treated with cefaclor suspension,and the observation group was treated with Chaihu Guizhi Decoction on the basis of the control group.The clinical efficacy of the 2 groups was compared.Results:The total effective rate(90.00%)of the study group was significantly higher than that of the control group(77.50)(P<0.05).Compared with those before treatment,scores of TCM syndromes,serum PCT,IL-6 and IL-8 levels in the 2 groups were all decreased,and the study group was significantly lower than the control group(P<0.05).Compared with that in the pre-treatment group,the transverse diameter of mesenteric lymph nodes in the 2 groups were shortened after treatment,and the study group was significantly shorter than the control group(P<0.05).Conclusion:Chaihu Guizhi Decoction can effectively treat children with mesenteric lymphagitis,improve the TCM syndrome score,speed up the time for symptom disappearance,relieve pain,and shorten the size of transverse diameter of abdominal mesenteric lymph nodes in child patients,with significant curative effects. |
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