| 引用本文:王慧，陈小平，谢波，江婷婷，黄虹.针灸联合复方左归胶囊对卵巢储备功能低下的影响及其作用机制[J].世界中医药,2020,(09):. |
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| 针灸联合复方左归胶囊对卵巢储备功能低下的影响及其作用机制 |
| Research on Effects of Acupuncture and Moxibustion Combined with Compound Zuogui Capsules on Low Ovarian Reserve Function and Its Mechanism |
| 投稿时间：2019-03-19 |
| DOI：10.3969/j.issn.1673-7202.2020.09.024 |
| 中文关键词: 卵巢储备功能低下 针灸 复方左归胶囊 肾虚证 健康宣教 性激素水平 临床症状积分 生命质量评分 不良反应 |
| English Keywords:Low ovarian reserve function Acupuncture Compound Zuogui Capsule Kidney deficiency syndrome Health education Sex hormone level Clinical symptom score Quality of life score Adverse reactions |
| 基金项目:广东省中医药局科研项目（20184004） |
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| 中文摘要: |
| 目的：分析针灸联合复方左归胶囊治疗卵巢储备功能低下(DOR)的临床疗效。方法：选取2018年3月至2018年10月广东省第二中医院收治的DOR患者50例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组25例。对照组采用戊酸雌二醇+黄体酮胶丸治疗，观察组采用针灸联合复方左归胶囊治疗。2组患者均连续治疗3个月。比较2组治疗后3个月、6个月、9个月的中医症状积分变化，临床疗效、血清促卵泡成熟激素(FSH)、黄体生成激素(LH)、雌二醇(E2）、生命质量评分（SF-36）以及药物不良反应比较。结果：2组患者治疗后中医症状积分、FSH、L均较治疗前下降，观察组下降趋势较对照组明显，差异有统计学意义（P<0.05）；观察组临床治疗有效率均高于对照组，差异有统计学意义（P<0.05）；治疗后9个月2组患者E2、SF-36各维度评分均较治疗前升高，且观察组优于对照组，差异有统计学意义（P<0.05）。2组患者治疗过程中均无严重药物不良反应，观察组患者一般不良反应率低于对照组，差异有统计学意义（P<0.05）。结论：针灸联合复方左归胶囊可有效治疗DOR，且不良反应少，明显提升患者生命质量。 |
| English Summary: |
| To analyze the clinical efficacy of acupuncture combined with compound Zuogui Capsules in the treatment of low ovarian reserve function(DOR).Methods:A total of 50 patients with DOR admitted to the Guangdong Second Traditional Chinese Medicine Hospital from March 2018 to October 2018 were selected as the research objects, and were randomly divided into a control group(n＝25)and an observation group(n＝25).The control group was treated with estradiol valerate plus progesterone Capsule, and the observation group was treated with acupuncture combined with compound Zuogui Capsules.Patients in both groups were treated continuously for 3 months.The changes of TCM syndrome score, clinical efficacy, serum FSH, LH, E2, quality of life score(SF-36)and adverse drug reactions were compared between the 2 groups at 3 months, 6 months and 9 months after treatment.Results:After treatment, the scores of TCM symptoms, FSH and LH in the observation group were significantly lower than those in the control group.The decreasing trend of the observation group was more obvious than that of the control group(P<0.05);the total effective rate of clinical treatment in the observation group was higher than that in the control group, and the dimensional scores of E2 and SF-36 in the 2 groups were higher 9 months after treatment, and the observation group was better than the control group(P<0.05).There were no serious adverse drug reactions in both groups, and the general adverse reaction rate in the observation group was lower than that in the control group(P<0.05).Conclusion:Acupuncture combined with compound Zuogui Capsule can effectively treat DOR, with less adverse reactions and can significantly improve the quality of life of patients. |
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