Based on the method of network pharmacology，the potential mechanism of Baicalin on pulmonary fibrosis was discussed from the systematical level.Methods:The information of baicalin compounds was obtained from NCBI pubchem，ZINC and TCMSP.The target of baicalin was obtained from NCBI database and Pharmmapper database.The target of pulmonary fibrosis was obtained from Disease Gene Network and Drug Bank.The potential target of Baicalin in the treatment of pulmonary fibrosis were predicted by gene mapping.A high confidence PPI network for baicalin in the treatment of pulmonary fibrosis was established in STING database.The important target and core path of topological were obtained by using topological analysis and enrichment analysis.Results:A total of 332 targets of baicalin，431 targets of pulmonary fibrosis and 45 potential targets of baicalin were obtained.A high confidence PPI network with 45 nodes and 191 edges was established.A total of 21 topologically important targets，3 core action pathways，20 biological processes (BP)，4 cell components (CC) and 4 molecular functions (MF) involved in baicalin treatment of pulmonary fibrosis were obtained.Conclusion:From the perspective of network pharmacology，the mechanism of Baicalin in the treatment of pulmonary fibrosis involves multiple targets and signal pathways.These targets and pathways are mainly related to the regulation of inflammation，apoptosis and other physiological and pathological processes related to the treatment of pulmonary fibrosis，which provides a network pharmacology framework for the future research of traditional Chinese medicine.