To observe the clinical therapeutic effects of Radix Bupleuri plus Longgu Muli Decoction，the classical prescription，in the treatment of coronary heart disease with depression.Methods:A total of 126 cases patients with coronary heart disease and depression admitted to the Department of Traditional Chinese Medicine of Shaanxi Provincial People's Hospital from January 2015 to June 2017 were selected as the research objects according to the method of random number table，and were randomly divided into a control group and an observation group，with 63 cases in each group.The control group was given conventional Western medicine therapy，and the observation group was given the Radix Bupleuri plus Longgu Muli Decoction，the classical prescription on the basis of the control group.Patients in both groups received 1 course of treatment for 3 months; the changes of TCM symptom scores，echocardiography，serum inflammatory factors and lipid metabolism levels in the 2 groups were observed; Five dimensional health scale score (EQ-5D) and Hamilton depression scale (HAMD) were used to evaluate life treatment and the degree of depression.Results:After treatment，the scores of chest tightness，chest pain，irritability and LVESD in the observation group were lower than those in the control group (P<0.05)，and LVEF，CO，SV were higher than those in the control group (P<0.05).After treatment，IL-6，CRP，TNF-α，TG，TC and LDL-C in observation group were lower than those in control group (P<0.05).There was no significant difference between observation group and the control group (P<0.05).After treatment，EQ-5D in the observation group was higher than that in the control group，and HAMD was lower than that in the control group (P<0.05).Conclusion:Under the guidance of the concept of “treatment of both psycho and cardiology”，the Radix Bupleuri plus Longgu Muli Decoction，classical prescription combined with Western medicine conventional treatment can effectively alleviate the clinical symptoms of patients with coronary heart disease complicated with depression，improve heart function，reduce blood lipid level，improve the quality of life，which is worthy of promotion.