| To investigate the effect of Zishen Huoxue Fang combined with valsartan on early diabetic nephropathy (EDN).Methods:A total of 102 EDN patients admitted to Baogang Hospital in Inner Mongolia from May 2017 to February 2018 were randomly divided into the control group and the observation group,with 51 cases in each group. Patients in the control group were treated with Valsartan capsule on the basis of conventional therapy, and patients in the observation group were treated with nourishing kidney and activating blood circulation therapy on the basis of the control group. The differences in inflammatory factors, blood glucose, blood lipids, renal function and clinical efficacy were compared between the two groups before and after treatment. Results:The total effective rate of the observation group (88.23%) was higher than that of the control group (70.59%)(P<0.05).Compared with before treatment, the levels of tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (h-CRP),cholesterol(TC),triglyceride(TG), low-density lipoprotein cholesterol (LDL-C),preprandial blood glucose (FBG),postprandial blood glucose (2hBG) and glycated hemoglobin (HbA1c),24 hour urine protein quantitation (24UPr),blood urea nitrogen (BUN), blood creatinine (Scr), urine protein excretion rate (UARE) reduced,and the observation group was lower than the control group (P<0.05). After treatment, the high-density lipoprotein cholesterol (HDL-C) of the two groups of patients increased, and the observation group was higher than the control group (P<0.05).Conclusion:Zishen Huoxue fang combined with valsartan was effective in the treatment of EDN, it can reduce blood sugar and lipid, reduce inflammation, and improve renal function, and it was worthy of clinical application. |
