To study the therapeutic effects of Bushen Qiangdu Decoction combined with sulfasalazine on ankylosing spondylitis(AS)and its effects on inflammatory factors and lumbar spine function.Methods:A total of 88 cases of patients with AS treated Yantai Hospital of Traditional Chinese Medicine were selected and divided randomly into a control group and an experiment group，with 44 cases in each group.The control group was treated with sulfasalazine tables，and the experiment group added Bushen Qiangdu Decoction on the basis of control group.Both groups took the drug continuously for 2 months.The clinical therapeutic effects were compared between the 2 groups; and the improvement of morning stiffness time，pain degree，Bath function index(BASFI)，Bath disease activity index(BASDAI)，Dougados index，finger distance and pillow wall distance of the 2 groups before and after treatment were observed; the levels of serum inflammatory factors were measured and compared between the 2 groups.Results:The total effective rate was 95.45% in the experiment group，which was higher than 81.82% in the control group(P<0.05).After treatment，the morning stiffness time，finger distance and pillow wall distance in the 2 groups shortened，BASFI，BASDAI，VAS scores，Dougados index and serum IL-4，IL-12，TNF-α，CRP levels decreased，and those in the experiment group were lower than those in the control group(P<0.05).Conclusion:Bushen Qiangdu Decoction combined with sulfasalazine can effectively reduce pain and serum inflammatory factor levels in AS patients，improve clinical symptoms，lumbar spine function，joint function，and improve the overall therapeutic effects.