| 引用本文:王富，曾庆宁，符之月.三子养亲汤合麻杏甘石汤加减辨治慢性阻塞性肺疾病痰热壅肺证[J].世界中医药,2020,(10):. |
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| 三子养亲汤合麻杏甘石汤加减辨治慢性阻塞性肺疾病痰热壅肺证 |
| Modified Sanzi Yangqin Decoction and Maxing Ganshi Decoction in the Treatment of Phlegm-heat Obstructing Lung Syndrome of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| 投稿时间：2019-03-20 |
| DOI：10.3969/j.issn.1673-7202.2020.10.019 |
| 中文关键词: 慢性阻塞性肺疾病 急性加重期 痰热壅肺证 三子养亲汤 麻杏甘石汤 肺功能 气道炎症指标 作用机制 |
| English Keywords:Chronic obstructive pulmonary disease Acute exacerbation stage Phlegm-heat obstructs lung syndrome Sanzi Yangqin Decoction Maxing Ganshi Decoction Lung function Airway inflammation index Mechanism of action |
| 基金项目:海南省自然科学基金项目（816385） |
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| 中文摘要: |
| 目的：探讨三子养亲汤合麻杏甘石汤加减治疗慢性阻塞性肺疾病急性加重期（AECOPD）痰热壅肺证的临床效果及作用机制。方法：选取2017年1月至2018年3月琼海市人民医院收治的AECOPD患者60例作为研究对象，按照随机数字表法随机分为观察组和对照组，每组30例，对照组患者给予西医常规治疗，观察组患者在此基础上加用由三子养亲汤合麻杏甘石汤加减而成的汤剂内服，2周为1个疗程。比较2组的临床疗效，观察2组的症状的缓解时间、肺功能、气道炎症指标水平变化。结果：观察组有效率90.0%，高于对照组的76.67%（P<0.05）；观察组患者的主要症状的缓解时间明显短于对照组（P<0.05）；观察组患者经治疗后的肺功能PEF、FVC、FEV1、FEV1/FVC水平，与对照组比较升高明显（P<0.05）；观察组患者经治疗后的血清因子IL-23、G-CSF、IGF-I水平，与对照组比较降低明显（P<0.05）。结论：三子养亲汤合麻杏甘石汤加减治疗利于促进痰热壅肺证AECOPD患者临床症状的缓解及消退，改善肺功能，降低血清中IL-23、G-CSF、IGF-I水平以减轻气道炎症损伤，值得临床推广运用。 |
| English Summary: |
| To observe the clinical efficacy of modified Sanziyangqin Decoction and Maxingganshi Decoction in the treatment of phlegm-heat obstructing lung syndrome of patients with acute exacerbation of chronic obstructive pulmonary disease,and explore the possible mechanism.Methods:A total of 60 cases of patients with phlegm-heat obstructing lung syndrome in acute exacerbation of chronic obstructive pulmonary disease in Qionghai People's Hospital were randomly divided into a control group and an observation group with 30 cases each.The control group was given conventional treatment with Western Medicine,while the observation group was taken orally with a decoction made from Sanzi Yangqin Decoction and Maxing Ganshi Decoction on this basis,and the course of treatment was 2 weeks.The the clinical effects,symptoms relief time,lung function and airway inflammation index levels were compared between the 2 groups.Results:The effective rate of the observation group was 90.0%,which was higher than that of the control group 76.67% (P<0.05).The remission time of main symptoms in the observation group was significantly shorter than that in the control group (P<0.05 ).The lung function of patients in the observation group was significantly improved after treatment,and the levels of PEF,FVC,FEV1 and FEV1/ FVC were significantly increased compared with the control group (P<0.05).The serum levels of serum factor IL-23,G-CSF and IGF-I in the observation group after treatment were significantly lower than those in the control group (P<0.05).Conclusion:For phlegm-heat obstructing lung syndrome patients with AECOPD,Modified Sanzi Yangqin Decoction combined with Maxing Ganshi Decoction is conducive to promoting the alleviation and regression of clinical symptoms,improving lung function,and reducing serum IL-23,G-CSF and IGF-I levels in order to reduce airway inflammation and injury,and is worthy of clinical promotion and application. |
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