| 引用本文:李晓玲，赵恒立，宋志超，汪海玥，张妍妍，杨峰，齐文蓉，吕明钊.补肾强督汤联合督灸治疗强直性脊柱炎的疗效观察[J].世界中医药,2020,(10):. |
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| 补肾强督汤联合督灸治疗强直性脊柱炎的疗效观察 |
| Effect of Bushen Qiangdu Decoction Combined with Moxibustion on the Meridian with Ankylosing Spondylitis |
| 投稿时间：2020-03-27 |
| DOI：10.3969/j.issn.1673-7202.2020.10.022 |
| 中文关键词: 强直性脊柱炎；补肾强督汤；督灸；腰椎功能；关节痛感 红细胞沉降率 肿瘤坏死因子-α 白细胞介素-6 |
| English Keywords:Ankylosing spondylitis Bushen Qiangdu Decoction Moxibustion on the Du meridian Lumbar spine function Joint pain Erythrocyte sedimentation rate Tumor necrosis factor-α Interleukin-6 |
| 基金项目:山东省科技计划项目（2015WS049） |
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| 中文摘要: |
| 目的：探究补肾强督汤联合督灸对强直性脊柱炎患者腰椎功能及红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α）水平的影响。方法：选取2015年6月至2017年10月烟台市中医医院收治的强直性脊柱炎患者87例作为研究对象，按照随机数字表法随机分为对照组（n=44）和观察组（n=43）。2组均接受常规西药治疗，观察组在此基础上予以补肾强督汤联合督灸治疗，2组均治疗8周。观察并比较2组临床疗效、腰椎功能、关节痛感、中医症候积分、体征以及ESR水平、血清TNF-α、IL-6水平。结果：观察组总有效率为95.45%，高于对照组的72.09%（P<0.05）。治疗后，2组功能评分、脊柱痛评分、中医症候积分、指地距均降低，观察组均低于对照组（P<0.05）；腰椎活动度、Schober试验比较均升高，观察组均高于对照组（P<0.05）。治疗后，2组ESR、血清TNF-α、IL-6水平均降低，观察组均低于对照组（P<0.05）。结论：补肾强督汤联合督灸可降低强直性脊柱炎患者ESR、TNF-α、IL-6水平，减轻疼痛，提高关节功能，进而改善中医症候及体征。 |
| English Summary: |
| To investigate the effects of Bushen Qiangdu Decoction combined with moxibustion on the Du meridian on lumbar spine function and erythrocyte sedimentation rate(ESR)，tumor necrosis factor-α(TNF-α)levels in patients with ankylosing spondylitis.Methods:From June 2015 and October 2017，a total of 87 patients with ankylosing spondylitis treated in rheumatology department of Yantai Traditional Chinese Medicine Hospital were randomly divided into a control group(n＝44)and an observation group(n＝43).Both groups were treated with conventional Western medicine.On the basis of this，the observation group was treated with Bushen Qiangdu Decoction combined with moxibustion on the Du meridian.Both groups were treated for 8 weeks.The clinical therapeutic effects，lumbar function，joint pain，TCM symptom scores，signs and ESR level，serum TNF-α，and IL-6 levels were compared between the 2 groups.Results:The total effective rate of patients in the observation group was 95.45%，which was higher than 72.09% in the control group(P<0.05).After treatment，the function score，spinal pain score，TCM symptom score and finger-to-ground distance of the 2 groups decreased，and those in the observation group were lower than those in control group(P<0.05); the lumbar spine activity and the Schober test both increased.Those in the observation group were higher than those in the control group(P<0.05).After treatment，the levels of ESR，serum TNF-α，and IL-6 in the 2 groups were lower than those in the observation group.Those in the observation group were lower than those in the control group(P<0.05).Conclusion:Bushen Qiangdu Decoction combined moxibustion on the Du meridian can reduce the levels of ESR，TNF-α and IL-6 in patients with ankylosing spondylitis，reduce pain，improve joint function，and then improve TCM symptoms and signs. |
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