| 引用本文:欧阳炜，朱雅玲，洪笃云.响应面法优选达原饮颗粒的提取工艺[J].世界中医药,2020,(11):. |
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| 响应面法优选达原饮颗粒的提取工艺 |
| Optimization of Extracting Technology of Dayuanyin Granules by Box-Behnken Surface Method |
| 投稿时间：2019-04-11 |
| DOI：10.3969/j.issn.1673-7202.2020.11.011 |
| 中文关键词: 达原饮颗粒 提取工艺 Box-Behnken响应面法 含量测定 厚朴酚 和厚朴酚 瘟疫 经典方 |
| English Keywords:Dayuan Granules Extraction technology Box-behnken response surface method Content determination Magnolol Honokiol Pestilence Classic prescriptions |
| 基金项目:创新中药研发平台建设项目/广东省科技计划项目(2017A070701017) |
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| 中文摘要: |
| 目的：优选达原饮颗粒的最佳提取工艺。方法：采用Box-Behnken响应面法，以浸膏得率与厚朴酚、和厚朴酚含量的总评归一值为评价指标，对达原饮颗粒提取工艺条件进行优选。结果：得到达原饮颗粒的最优值为提取次数2.42次，提取时间0.96 h，加溶剂量10倍，预测值OD=0.948，根据实际生产选择最优条件为提取时间55 min，加水量10倍，提取2次，OD=0.895。结论：优选得到的提取工艺经验证重复性高，结果稳定。 |
| English Summary: |
| To optimize extraction process of Dayuan Granules.Methods:Based on Box-Behnken design-response surface method,the sum of the extraction yield,magnolol,and magnolol content were the evaluation index and the extraction process conditions of Dayuanyin Granules was optimized.Results:The optimal value of Dayuanyin Granules was 2.42 extraction times,0.96 h extraction time,10 times the amount of solvent added,and the predicted value OD=0.948.According to the actual production,the optimal conditions were selected as 55 minutes extraction time and 10 times the amount of water added.Extracted twice,OD=0.895.Conclusion:The optimized extraction process has been verified to have high repeatability and stable results. |
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