To observe the therapeutic effects of baicalin-mediated photodynamic therapy (PDT) on cervical cancer and explore its possible mechanism. Methods:A cervical cancer Hela cell suspension was injected subcutaneously into nude mice to construct a transplanted tumor model. After the model was formed, it was randomly and evenly divided into 4 groups: a model group, a baicalin-PDT treatment group, a PDT treatment group, and a curcumin-PDT treatment group , with 18 cases in each group. PDT treatment group: 100μL of saline was injected around the tumor, and 100 μL of borax buffer was injected around the tumor 6 hours later, followed by PDT treatment. The irradiation dose was 80J/cm2 (435nm wavelength, 0.60A, 0.54W, 3-5cm from the tumor surface, irradiation 2 min28s); Baicalin-PDT treatment group: 100 μL of baicalin solution at 80 μg/mL instead of normal saline, others were the same as PDT treatment group; curcumin-PDT treatment group: 50 μmol/L curcumin solution instead of 100 ml normal saline, others were the same as PDT treatment group; model group: natural light instead of PDT treatment, others were the same as PDT treatment group. After 1 day of treatment, 6 rats were sacrificed in each group and their tumor tissues were prepared for pathological sections, and the histopathological changes were observed by HE staining; another 6 were sacrificed, and the expression of Bcl-2 and Bax proteins in tumor tissues were detected by Western blot technology; their tumor volume of 6 remaining rats, was measured only on the 1st, 3rd, 7th, and 14th days of treatment, and the tumor volume inhibition rate was also calculated. Results:The tumor volume in the model group continued to increase. Tumor tissue appeared necrosis and tumor growth was inhibited after 1 day of photodynamic therapy. The tumor volume of baicalin-PDT treatment group and curcumin-PDT treatment group did not increase within 3 days, and then gradually increased. The expression of Bcl-2 and Bax proteins in the baicalin-PDT treatment group was significantly different from that in the model group (P<0.01). Conclusion:Baicalin-mediated PDT can effectively inhibit the growth of cervical cancer xenografts in vitro, and its mechanism may play a role in promoting cancer cell apoptosis.