| 引用本文:朱文忠，童舟，徐涛.斑蝥酸钠维生素B6联合化疗对肺癌疗效分析[J].世界中医药,2020,(11):. |
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| 斑蝥酸钠维生素B6联合化疗对肺癌疗效分析 |
| Analysis of the Efficacy of Sodium Cantharidin And Vitamin B6 Combined with Chemotherapy on Lung Cancer |
| 投稿时间：2020-03-02 |
| DOI：10.3969/j.issn.1673-7202.2020.11.019 |
| 中文关键词: 肺癌 培美曲塞二钠 顺铂 斑蝥酸钠维生素B6 治疗效果 |
| English Keywords:Lung cancer Pemetrexed disodium Cisplatin Sodium cantharidin Vitamin B6 Therapeutic effects |
| 基金项目:安徽省自然科学基金项目（1608085QH214） |
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| 中文摘要: |
| 目的：观察化疗联合斑蝥酸钠维生素B6治疗肺癌的效果。方法：选取2017年1月至2019年10月池州市人民医院收治的晚期肺腺癌患者66例作为研究对象，按照用药方法不同分为对照组与观察组，每组33例，对照组通过顺铂联合培美曲塞二钠方案化疗治疗，观察组在此基础上联合斑蝥酸钠维生素B6治疗，比较2组治疗效果，以及用药前后生命质量评分（FACT-L）、癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白19片段（CA21-1）等改变以及药物不良反应。结果：与对照组比较，观察组的近期治疗效果更优（P<0.05）；治疗后观察组生命质量评分明显高于对照组（P<0.05）；2组CEA、NSE、CA21-1等水平比较差异有统计学意义（P<0.05）；观察组不良反应发生率明显低于对照组（P<0.05）。结论：以化疗联合斑蝥酸钠维生素B6治疗能够使肺癌患者的生命质量明显提升，降低不良反应发生率，使肺癌标志性指标明显改善，对延长患者的生存时间有积极意义。 |
| English Summary: |
| To analyze the effects of chemotherapy combined with sodium cantharidin and vitamin B6 in patients with lung cancer.Methods:A total of 66 patients with advanced lung adenocarcinoma treated in Chizhou People's Hospital from January 2017 to October 2019 were selected as the research objects.They were divided into a control group and an experimental group,wit 33 cases in each group.The control group was treated with cisplatin combined with pemetrexed disodium; the experimental group was treated with sodium cantharidin and vitamin B6 based on the control group.Changes in the treatment effects,quality of life score(FACT-L),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),cytokeratin 19 fragment(CA21-1),and drug side effects before and after treatment were compared.Results:Compared with the control group,the short-term treatment effects were better in the experimental group(P<0.05); the quality of life score of the experimental group was significantly higher than that of the control group(P<0.05); In the experimental and control groups,CEA,NSE,and CA21-1 levels were significant(P<0.05); the incidence of side effects in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion:The treatment of lung cancer patients with chemotherapy combined with sodium cantharidin and vitamin B6 can significantly improve the quality of life of patients,reduce the incidence of toxic and side effects,and significantly improve the landmark indicators of lung cancer,which has a positive significance for prolonging the survival time of patients. |
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