To explore the material basis and mechanism of Shengmai San (SMS) in the treatment of COVID-19 during the recovery period using network pharmacology. Methods:The meridian tropism and composition of each herb in SMS were searched from TCMSP, online analysis platform (ETCM, TCMID, HIT), Chemdb database and chinese pharmacopoeia. Then, PharmMapper database, DrugBank, E-TCM and Swiss Target Prediction platforms were used to predict potential targets of components of SMS. The interaction between proteins of SMS drug components and the key targets of COVID-19 were analyzed by using String database, Cytoscape software was used for network construction and analysis. Finally, DAVID platform and FunRich databases were used for enrichment analysis of candidate targets. Results:It was found that the meridian tropism of the three Chinese herbs in SMS are all lung meridian. A total of 21 chemical components that meet the screen standard were selected from the SMS compound, including common saponin compounds such as ginsenoside Rh4, alcohol compounds such as β-sitosterol, lignan compounds such as schisandrin, and other chemical components such as alkaloids, flavonoids and terpenes. In addition, 457 targets related to the chemical compositions from SMS were predicted, and 51 targets related with COVID-19 disease were obtained. String analysis found that there were close interactions between the 70 targets of the chemical components and the 29 targets of COVID-19; The pathway enrichment analysis showed that the pathways enriched by candidate targets mainly included multiple cancer-related pathways, FoxO signaling pathway, viral carcinogenesis signaling pathway, etc. Conclusion:This paper preliminarily explored the material basis and action mechanism of SMS for the treatment of COVID-19 during the recovery period based on network pharmacology. These results will provide important information for further study.