| 引用本文:鲁春花1，赵凯2，萨震2，王华兴2，覃彩孟1，高雪2，刘岩松1，卢涛1.大黄黄连泻心汤对幽门螺旋杆菌感染的系统药理学研究[J].世界中医药,2020,(12):. |
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| 大黄黄连泻心汤对幽门螺旋杆菌感染的系统药理学研究 |
| Systematic Pharmacological Study on Dahuang Huanglian Xiexin Decoction on Helicobacter Pylori Infection |
| 投稿时间：2020-01-23 |
| DOI：10.3969/j.issn.1673-7202.2020.12.005 |
| 中文关键词: 大黄黄连泻心汤 幽门螺旋杆菌 系统药理学 胃癌 网络分析 |
| English Keywords:Dahuang Huanglian Xiexin Decoction Helicobacter pylori Systematic pharmacology Gastric cancer Network analysis |
| 基金项目:北京中医药大学卢涛研究启动经费项目(1000041510053) |
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| 中文摘要: |
| 目的:运用系统药理学探讨大黄黄连泻心汤对治疗幽门螺旋杆菌感染的分子作用机制,挖掘潜在的作用靶点和信号通路。方法:首先利用中医药整合数据库(SymMap)筛选大黄黄连泻心汤的潜在作用靶点;从比较毒理基因组学数据库(CTD)发现幽门螺旋杆菌感染的相关疾病靶点;将筛选后的靶点输入到String中构建“大黄黄连泻心汤-幽门螺旋杆菌”的蛋白质相互作用网络(PPI);采用在线分析工具WebGestalt对筛选出的靶点进行GO功能注释和KEGG通路富集分析。结果:获得大黄黄连泻心汤和幽门螺旋杆菌感染重合的靶点共有222个,通过PPI网络发现71个相互作用靶点,其中主要以IL6、MYC、VEGFA、CASP3、EP300、IL10、ERBB2、CDKN1A、MPO、NFE2L2为关键靶点;发现10个关键生物过程和10条关键信号通路。结论:大黄黄连泻心汤可能通过调节机体免疫炎性反应,发挥对幽门螺旋杆菌感染的治疗作用,同时可能通过抗肿瘤机制起到防止幽门螺旋杆菌感染进一步向更严重胃肠道疾病转化的作用。本研究为中医药治疗幽门螺旋杆菌提供了理论依据。 |
| English Summary: |
| To explore the molecular mechanism of Dahuang Huanglian Xiexin Decoction in the treatment of helicobacter pylori infection by systematic pharmacology，and to explore potential targets and signal pathways.Methods:First，the integrated Chinese medicine database (SymMap) was used to screen the potential targets of Dahuang Huanglian Xiexin Decoction; the relevant disease targets of helicobacter pylori infection was found from the comparative toxicology genomics database (CTD); the protein interaction network (PPI) of “Dahuang Huanglian Xiexin Decoction-Helicobacter pylori” was constructed in String after the screened target entered into it; the online analysis tool WebGestalt was used to perform GO function annotation and KEGG pathway enrichment analysis on the selected targets.Results:There were 222 overlapping targets of Dahuang Huanglian Xiexin Decoction and Helicobacter pylori infection coinciding.A total of 71 interactive targets were located through the PPI network.Among them，IL6，MYC，VEGFA，CASP3，EP300，IL10，ERBB2，CDKN1A，MPO and NFE2L2 were key targets; 10 key biological processes and 10 key signaling pathways were discovered.Conclusion:Dahuang Huanglian Xiexin Decoction may play a therapeutic role in the treatment of helicobacter pylori infection by regulating the body's immune inflammatory response and at the same time it may prevent the infection of helicobacter pylori from further transforming to more severe gastrointestinal diseases by anti-tumor mechanism.This study provides solid theoretical basis for TCM treatment of helicobacter pylori. |
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