To investigate and analyze the effects of invigorating qi, invigorating kidney and activating blood circulation method on plasma prothrombin time (PT), tissue plasminogen activator (t-PA), serum vascular endothelial growth factor (VEGF),total cholesterol (TCH),and low-density lipoprotein (LDL) in femur head necrosis model rats. Methods:A total of 60 SD rats were divided into control group, model group and research group by random lottery. The rats in model group and the observation group were replicated the femoral head necrosis model. After the successful modeling, the rats in the research group were treated with the method of invigorating qi, enriching kidney and activating blood circulation. The femoral head density, serum phosphorus and calcium, plasma PT and t-PA, serum VEGF, TCH and LDL were compared. Results:The femoral head density of the model group was lower than the control group, while research group was higher than model group (all P<0.05). After model replication, serum phosphorus and calcium in the model group were lower than control group, while research group were higher than model group (all P<0.05).After model replication, plasma PT and t-PA in the model group were lower than control group, while research group were higher than model group (all P<0.05). After replication, the serum VEGF in the model group were lower than control group, while TCH and LDL were higher than control group. Serum VEGF in the research group were higher than model group, while TCH and LDL were lower than model group (all P<0.05). Conclusion:The method of invigorating qi, tonifying kidney and activating blood circulation can significantly improve the femoral head density, plasma PT, t-PA, serum VEGF, TCH and LDL levels in rats with femoral head necrosis. It is worthy of clinical application.