| 引用本文:蔡军，岳海振，周占国，关涛.补气益肾活血法对股骨头坏死模型大鼠血浆及血清指标的影响[J].世界中医药,2020,(12):. |
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| 补气益肾活血法对股骨头坏死模型大鼠血浆及血清指标的影响 |
| Effects of Invigorating Qi, Tonifying Kidney and Activating Blood Circulation Method on Plasma and Serum Indexes in Rats with Femoral Head Necrosis |
| 投稿时间：2019-08-23 |
| DOI：10.3969/j.issn.1673-7202.2020.12.007 |
| 中文关键词: 股骨头坏死 大鼠模型 补气益肾活血法 血管内皮生长因子 低密度脂蛋白 |
| English Keywords:Femoral head necrosis Rat model Invigorating qi, Enriching kidney and promoting blood circulation method Vascular endothelial growth factor Low density lipoprotein |
| 基金项目:国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015282)——补气益肾活血法治疗早中期股骨头坏死的临床研究 |
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| 中文摘要: |
| 目的:研究补气益肾活血法对股骨头坏死模型大鼠血浆凝血酶原时间(PT)、组织性纤溶酶原激活剂(t-PA)及血清血管内皮生长因子(VEGF)、总胆固醇(TCH)、低密度脂蛋白(LDL)的影响。方法:以随机抽签法将60只SD大鼠分成对照组、模型组以及观察组。模型组与观察组制作股骨头坏死模型,成功后,观察组另实施补气益肾活血法治疗。比较3组股骨头密度,血清磷、钙水平,血浆PT、t-PA,血清VEGF、TCH、LDL。结果:模型复制后模型组股骨头密度低于对照组,观察组高于模型组(均P<0.05)。模型复制后模型组血清磷、钙低于对照组,观察组高于模型组(均P<0.05)。模型复制后模型组血浆PT、t-PA低于对照组,观察组高于模型组(均P<0.05)。复制后模型组血清VEGF低于对照组,而TCH、LDL高于对照组;观察组血清VEGF高于模型组,而TCH、LDL低于模型组(均P<0.05)。结论:补气益肾活血法可显著改善股骨头坏死模型大鼠的股骨头密度,同时可改善血浆PT、t-PA及血清VEGF、TCH、LDL,值得推广。 |
| English Summary: |
| To investigate and analyze the effects of invigorating qi, invigorating kidney and activating blood circulation method on plasma prothrombin time (PT), tissue plasminogen activator (t-PA), serum vascular endothelial growth factor (VEGF),total cholesterol (TCH),and low-density lipoprotein (LDL) in femur head necrosis model rats. Methods:A total of 60 SD rats were divided into control group, model group and research group by random lottery. The rats in model group and the observation group were replicated the femoral head necrosis model. After the successful modeling, the rats in the research group were treated with the method of invigorating qi, enriching kidney and activating blood circulation. The femoral head density, serum phosphorus and calcium, plasma PT and t-PA, serum VEGF, TCH and LDL were compared. Results:The femoral head density of the model group was lower than the control group, while research group was higher than model group (all P<0.05). After model replication, serum phosphorus and calcium in the model group were lower than control group, while research group were higher than model group (all P<0.05).After model replication, plasma PT and t-PA in the model group were lower than control group, while research group were higher than model group (all P<0.05). After replication, the serum VEGF in the model group were lower than control group, while TCH and LDL were higher than control group. Serum VEGF in the research group were higher than model group, while TCH and LDL were lower than model group (all P<0.05). Conclusion:The method of invigorating qi, tonifying kidney and activating blood circulation can significantly improve the femoral head density, plasma PT, t-PA, serum VEGF, TCH and LDL levels in rats with femoral head necrosis. It is worthy of clinical application. |
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