To study the expectorant, antiasthmatic, antitussive, and antiinflammatory effects of Baofei Granules. Methods:The mice phenolsulfonphthalein excretion method was used to observe the expectorant effects. The guinea pigs asthma induced by histamine phosphate method was used to observe the antiasthmatic effects. The antitussive effects of the cough reaction in mice caused by SO2, and the anti-inflammatory effects of the auricle swelling caused by xylene, and the anti-inflammatory effects of the rat toe swell method induced by carrageenan were observed. Results:Experiments on mice auricular swelling inflammation model showed the high, medium and low dose groups of Baofei Granules could significantly inhibit the swelling of mice ears caused by xylene, and its swelling degree and swelling rate were significantly reduced; the expectorant(tracheal phenol red method)experiments on mice showed that Baofei Granules can increase the excretion of phenol red in high, medium and low doses. Anti-asthmatic(guinea-spray method)experiments on guinea pigs showed that high doses of Baofei Granules can significantly increase the prolongation rate of guinea pig asthma caused by histamine phosphate, and low and medium doses can also increase the prolongation rate of guinea pig asthma latency, but there was no statistical difference. The relieving cough(sulfur dioxide cough method)experiment on mice showed that high, medium and low doses of Baofei Granule can significantly prolong the incubation period of cough caused by SO2 in mice; high and medium doses can significantly reduce the number of coughs in 2 minutes; high and low Baofei Granules can significantly prolong the incubation period of guinea pig cough caused by citrate, can significantly reduce the number of coughs within 5 minutes, and the prolongation rate of incubation period has been significantly improved. Conclusion:Baofei Granules has significant expectorant, antiasthmatic, antitussive, and antiinflammatory effects.