To evaluate the clinical efficacy of Weikang Capsules combined with proton pump inhibitor(PPI)in the treatment of upper gastrointestinal ulcers. Methods:A total of 65 patients with upper gastrointestinal ulcers diagnosed in Huainan First People's Hospital from January 2016 to December 2017 were selected and randomly divided into a control group(n=33)and an observation group(n=32). The control group was treated with intravenous infusion of azole drugs based on the situation of patients. The observation group was treated with Weikang Capsules on the basis of the treatment of the control group, and the intervention lasted for 4 weeks to compare the Hp eradication rate, endoscopic symptoms and treatment safety of the 2 groups before and after treatment. And the quality of life of the 2 groups of patients was compared followed Outpatient follow-up for 4 weeks. Results:The improvement of symptoms, healing of ulcer surface, and Hp clearance in the observation group were significantly better than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the 2 groups of patients(P>0.05). After 6 months of Outpatient follow-up, the three dimensions of QLICD-GM score in the observation group was significantly better than those in the control group and those before treatment(P<0.05). Conclusion:Weikang Capsules combined with PPI can significantly improve the eradication rate of Hp in patients with upper gastrointestinal ulcers, clinical symptoms, and quality of life of patients in the near future, and have good treatment safety, which is worthy of clinical promotion and application.