To explore the correlation between TCM classification and oxidative stress of uremic acid nephropathy.Methods:A retrospective analysis was used to analyze 105 cases of uremic acid nephropathy from December 2017 to September 2019，and 105 cases healthy people at the same period of were selected as the control group.Referring to Guidelines for Clinical Research on New Drugs of Traditional Chinese Medicine and combining 105 cases of uric acid nephropathy with common clinical syndromes，105 cases of uremic acid nephropathy were divided into 18 cases of qi deficiency of spleen and kidney，19 cases of deficiency of both qi and yin，16 cases of yin deficiency of liver and kidney，12 cases of deficiency of both yin and yang，19 cases of accumulated dampness-heat，17 cases of blood obstruction and stagnation，and 13 cases of phlegm and turbid internal obstruction.Venous blood was drawn on an empty stomach in the early morning of the day after admission to the hospital to detect oxidative stress and renal function damage indicators.The changes of oxidative stress indicators in different groups were compared，and the changes of TCM classification，oxidative stress and renal function damage indicators were compared.Results:1)The total antioxidant capacity (T-ACO)，advanced protein oxide (AOPP)，serum propylene glycol (MDA)，and superoxide dismutase (SOD) levels in the uric acid nephropathy group were (19.45±3.42) U/ mL，(42.45±3.53) μmol/L，(4.52±1.23) nmol/L，(76.78±5.64) U/mL.The normal control group was (10.76±1.31) U/mL，(20.84±1.28) μmol/L，(2.13±0.76) nmol/L，(130.85±16.75) U/mL，T-ACO，AOPP，MDA in uric acid nephropathy group were significantly higher than normal control group，SOD was significantly lower (P<0.05).2)The SOD content of deficiency of both yin and yang in deficiency syndrome was lower than other syndromes，while MDA，T-AOC，AOPP，Cystatin C (CysC)，β2 microglobulin，Urine Microalbumin (UMALB)，protein incidence of urine was higher than other syndrome types，and the difference is statistically significant (P<0.05).The empirical evidence of blood stasis block SOD content was lower than other syndrome types，while MDA，T-AOC，AOPP were higher than other syndrome types，and the difference was statistically significant (P<0.05).Conclusion:The indexes of oxidative stress and of renal damage in the TCM syndrome classification of both deficiency of yin and yang and stasis syndrome of uric acid nephropathy are significantly increased，which can be combined with the laboratory examination for clinical intervention.