Based on ultra-high performance liquid chromatography-quadrupole-orbitrap mass spectrometry(UPLC-Q-Orbitrap HRMS)technology，to thoroughly study the material basis of Weifuchun Tablets，and to quickly identify the main chemical components.Methods:The analysis was performed on a Thermo Hypersil GOLD C18 column(150 mm×4.6 mm，3 μm).The mobile phase comprised of water containing 0.05% formic acid and acetonitrile was used for gradient elution.Mass spectrometry adopts positive and negative ion detection mode，full scan and automatic trigger secondary mass spectrometry scan function(Full MS/dd MS2)to collect data.By comparing the compound's maximum ultraviolet absorption wavelength，accurate relative molecular mass and secondary fragment ion information with the reference substance retention time，mzVault 2.0 mass spectrometry database and related literature reports，the main chemical components of Weifuchun tablets were identified.Results:A total of 164 chemical constituents including 42 ginsenosides，97 flavonoids，19 diterpenoids and 6 other compounds，were identified.Conclusion:UPLC-Q-Orbitrap HRMS technology can quickly，accurately，and comprehensively identify the chemical composition of Weifuchun tablets，which provides a theoretical basis for clarifying the basic research of drug efficacy and improving quality standards.