To observe the effects of Shenpu Penyan Granules on endometritis induced by phenol mucilage and the explore anti-inflammatory mechanism.Methods:A total of 60 female SD rats were randomly divided into a sham operation group,a model group,a Shenpu Penyan Granules high dose group,a medium dose group and a low dose group (15.0,7.5,3.75 crude drugs g/kg) and Fuke Qianjing Capsule (5.0 g/kg).Rat model of endometritis was copied with phenol glue.After the rats were treated 21 days by intragastric administration,the content of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum of rats were determined by colorimetry.Pathological changes of endometrium of rates were evaluated by rats.Expressions of NF-kB in uterine tissue were detected by western blotting (WB).Results:Shenpu Penyan Granules could improve obviously the pathological damage of endometrial epithelial cell proliferation,degeneration,necrosis and inflammatory cell infiltration.Shenpu Penyan Granules high and medium dose group significantly increased the serum SOD content and decreased MDA content.And Shenpu Penyan Granules significantly reduced the content of IL-1β,TNF-a and NF-kB protein phosphorus level in rat uterine tissue.Conclusion:Shenpu Penyan Granules have a good therapeutic effects on phenol-induced endometritis in rats and its mechanism may be related to the inhibition of NF-kB pathway activation.