To explore the effects of Tongqiaohuoxue Decoction(tqhxd)on severe craniocerebral injury after minimally invasive hematoma removal.Methods:From May 1,2018 to April 30,2019,a total of 124 patients with severe craniocerebral injury undergoing minimally invasive hematoma removal in Guangzhou Integrative Chinese and Western Hospital were selected as the study objects.According to the hospitalization number,they were divided into 2 groups.The control group(n=62)was treated with routine treatment after operation.And the study group(n=62)was treated with modified oral treatment of Tongqiao Huoxue Decoction for 2 weeks on the basis of the control group.The changes of tumor necrosis factor-α(TNF-α)and interleukin-1(IL-1)were observed and compared in the 2 groups at different time points,and the changes of nerve function,hemorheology,hemodynamics and related scores were observed and compared in the 2 groups at the time of enrollment and at the completion of the treatment course.Results:The decrease of TNF-α,IL-1,GFAP,NSE,S100 β,blood viscosity,platelet aggregation index,vascular resistance index and pulsation index in the study group was larger than that in the control group(P<0.05).The maximum peak flow rate,average flow rate,MMSE,FCA,and GCS scores increased more than those in the control group(P<0.05)Conclusion:Tongqiao Huoxue Decoction can inhibit the inflammatory reaction and stress reaction of severe craniocerebral injury,improve cerebral microcirculation,promote the recovery of nerve function and improve the quality of life.