To observe the clinical efficacy of Corona Virus Disease(COVID-19)treated with “Pneumonia No.1 Formula.Methods:A total of 451 patients with Corona Virus Disease(COVID-19)admitted from February 17，2020 to March 15，2020 were treated with “Pneumonia No.1 Formula” combined with Western medicine routine treatment in Hubei Provincial Hospital of Traditional Chinese medicine，Jianli County Hospital of Traditional Chinese Medicine，Qichun County People's Hospital，Qianjiang City Hospital of Traditional Chinese Medicine，Honghu City Hospital of Traditional Chinese Medicine，Yangxin County Hospital of Traditional Chinese Medicine，Xishui County Hospital of Traditional Chinese Medicine，Daye City Hospital of Traditional Chinese Medicine，Hanchuan City People's Hospital，Wuhan Fangcang Hospital，and the clinical symptoms，tongue manifestation，experimental results and pulmonary CT were observed after “Pneumonia No.1 Formula” was used.Results:A total of 451 patients were included，including 21 cases of light type，378 cases of common type，46 cases of sever type and 6 cases of critical type.There were 6 suspected cases(1.33%)，168 clinically diagnosed cases(37.25%)，and 277 confirmed cases(61.42%).After treatment，compared with that before treatment，the incidence of fever，cough and fatigue was significantly reduced(P<0.05).The incidence of symptoms of aversion to cold，nasal obstruction，runny nose，sneezing，pharyngeal itch，sore throat，dyspnea，chest tightness，muscle ache or joint pain，dizziness，headache，tolerance，nausea and vomiting，abdominal distension，loose stool significantly improved(P<0.05).There was no significant difference in the white blood cell count and the absolute value of neutrophils(P>0.05).The absolute value of lymphocytes was significantly increased with significant difference(P<0.05).C-reactive protein and procalcitonin were significantly reduced with significant differences(P<0.05).Antipyretic time was 3(1～3.25)days.The tongue color of 229 patients gradually changed from red or purple to light red，and the improvement rate was 75.58%.The white greasy moss，thick greasy moss and yellow greasy moss significantly become thinned in 177 patients，with an improvement rate of 65.31%.The negative time of novel coronavirus nucleic acid was 8(5,11)days.In 415 cases(92.02%)，lung CT was better than before，mainly manifested in the decrease of lesion area，and thinning.A total of 430 cases reached the discharge standard，the clinical cure rate was 95.34%; 15 cases improved，3 cases ineffective，3 cases dead(0.67%).During the treatment，no significant adverse reactions were found，with good safety of clinical application.Conclusion:“Pneumonia No.1 Formula” combined with conventional Western medicine treatment has a good therapeutic effect on Corona Virus Disease(COVID-19)，which can quickly stabilize the condition and block the transformation from light and ordinary type to server and critical type.It significantly improves the clinical symptoms of the patients，and promotes the absorption of pulmonary inflammation.It's safe and reliable to use.