To study the effects of electroacupuncture combined with music therapy on cognitive function and activities of daily living (ADL) in patients with mild and moderate Alzheimer's disease.Methods:A total of 120 patients with mild and moderate Alzheimer's disease treated in the First Hospital of Zhangjiakou from January 2015 to August 2017 were divided into a control group and an observation group according to the random number table method,with 60 cases each group.The total clinical effective rate,cognitive function,self-care ability,behavioral and mental symptoms and life quality before and after treatment were compared,and the improvement of neurotransmitters of patients was evaluated by cholinergic system and monoamine system.Results:Before treatment,the difference was not statistically significant in general material between the 2 groups (P>0.05).After treatment,the total effective rate of the control group and the observation group was 81.67% and 91.67% respectively.After treatment,the scores of MMSE,MoCA,ADL,BEHAVE-AD and SF-36 in the 2 groups were significantly higher than those before treatment (P<0.05),and the above-mentioned indexes in the observation group were significantly higher than those in the control group (P<0.05).After treatment,the contents of acetylcholine,choline acetylase,norepinephrine,5-hydroxytryptamine and dopamine receptor in the 2 groups were significantly higher than those before treatment (P<0.05).The above-mentioned indexes in the observation group were significantly higher than those in the control group (P<0.05).Conclusion:Electroacupuncture combined with music therapy in the treatment of mild and moderate Alzheimer's disease could effectively improve patients' cognitive function and activities of daily life,which is worthy of clinical application.