| 引用本文:朱辰奇1,2，顾依2，周琴1，刘馨1，沈惠明1，陈志鹏2.利用聚多巴胺制备丹参注射液缓释制剂的研究[J].世界中医药,2020,(15):. |
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| 利用聚多巴胺制备丹参注射液缓释制剂的研究 |
| Study on Preparation of Danshen Injection Sustained-release Preparation Using Polydopamine |
| 投稿时间：2020-07-01 |
| DOI：10.3969/j.issn.1673-7202.2020.15.009 |
| 中文关键词: 丹参注射液 聚多巴胺 缓释制剂 高效液相色谱法 |
| English Keywords:Salvia miltiorrhiza injection Polydopamine Sustained-release preparation High performance liquid chromatography |
| 基金项目:国家重点研发计划项目(2018YFC1706905)——中医药现代化研究;苏州市科技发展计划基金项目(SYSD2019187,SYSD2018242) |
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| 中文摘要: |
| 目的:利用聚多巴胺(PDA)对丹参注射液中多成分进行负载,构建丹参注射液(SMI)缓释制剂(PDA-SMI)。方法:建立丹参注射液的原儿茶醛、迷迭香酸和丹酚酸B3种成分的分析方法并进行含量测定;制备PDA,在pH值2.5的条件下对SMI进行负载,制备PDA-SMI;对PDA-SMI体外释放行为进行考察。结果:SMI中原儿茶醛、迷迭香酸、丹酚酸B的浓度分别为0.344、0.214、0.262 mg/mL;PDA-SMI对原儿茶醛、迷迭香酸、丹酚酸B的载药量分别为8.59%,15.90%和20.57%;PDA-SMI中原儿茶醛、迷迭香酸、丹酚酸B体外累计释放率分别为84.05%,77.57%和63.12%。结论:PDA可以负载SMI的多种成分,载药量较高,并具有良好的缓释效应。 |
| English Summary: |
| To use polydopamine(PDA)to carry out multiple components of Salvia miltiorrhiza injection,and to construct a slow-release preparation of Salvia miltiorrhiza injection(SMI)(PDA-SMI).Methods:Establish the analysis method of the three components of protocatechuic aldehyde,rosmarinic acid and salvianolic acid B of Salvia miltiorrhiza injection and determine the content; prepare PDA,load SMI under the condition of pH 2.5 to prepare PDA-SMI; The in vitro release behavior of PDA-SMI was investigated.Results:The concentrations of protocatechuic aldehyde,rosmarinic acid and salvianolic acid B in SMI were 0.344,0.214 and 0.262 mg/mL,respectively; the loading of protocatechuic aldehyde,rosmarinic acid and salvianolic acid B by PDA-SMI The doses were 8.59%,15.90% and 20.57% respectively; the cumulative release rates of protocatechuic aldehyde,rosmarinic acid and salvianolic acid B in PDA-SMI were 84.05%,77.57% and 63.12%,respectively.Conclusion:PDA can load multiple components of SMI and has a good sustained-release effect. |
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