To compare the clinical effects and safety of Jingxin Gengnian Tablets and Shugan Jieyu Capsules in the treatment patients with male climacteric syndrome.Methods:A total of 63 patients with male climacteric syndrome admitted to Xi'an Hospital of Traditional Chinese Medicine were divided into a control group and an observation group by random number table method with 34 cases in each group.The control group was given Shugan Jieyu Capsules orally,and the observation group was given Jingxin Gengnian Tablets orally.The clinical effects,symptom scores,serum sex hormone and bad mood of the 2 groups were compared.Results:The effective rate of clinical treatment in the observation group was significantly higher than that in the control group (P<0.05).After treatment,the psychosocial symptoms,physical/vasomotor symptoms and sexual function symptom scores,hamilton anxiety scale score (HAMA),hamilton depression scale score (HAMD),serum total testosterone (TT),free testosterone (FT),sex hormone binding globulin (SHBG),follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels in the 2 groups were significantly better than before treatment (P<0.05),and difference between the 2 groups is statistically significant (P>0.05); there was no significant difference in the incidence of adverse reactions between the 2 groups (P>0.05).Conclusion:Compared with Shugan Jieyu Capsules,Jingxin Gengnian Tablets is more conductive to improve the level of serum sex hormone in patients with male climacteric syndrome,and to improve their mental,physical and cardiovascular status and sexual function.